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首页> 外文期刊>Journal of Cancer Research and Treatment >Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats
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Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats

机译：银杏叶提取物对甲氨蝶呤致大鼠肝肾毒性的抑制作用

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Methotrexate (MTX) is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. The present study aimed to examine the possible modifying effects of Ginkgo biloba leaf extract (GLE) against hepatic and renal toxicity induced by MTX in rats. A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and GLE groups respectively while the 3rd group was MTX rat group; the 4th and 5th groups were Co- and post treated MTX rat with GLE respectively and the 6th group was MTX self treated rat group. Serum GPT, GOT, urea, creatinine, uric acids and MDA levels in MTX group showed a significant increase when compared with control group, in contrast, MTX-treated group also exhibited a significant decrease in liver antioxidant machinery represented by GSH, catalase, SOD and total protein. Administration of GLE combined with MTX improved the liver and kidney damages induced by MTX. Histopathological and evidence, together with observed CD68 immunoreactivity, supported the detrimental effect of MTX and the ameliorating effect of GLE on liver and kidney toxicities. GLE possessed various protective mechanisms against MTX-induced liver and kidney toxicity throughout Co- and post- treatment. We can conclude that Co-treatment with GLE has beneficial properties and can reduce the liver and kidney damages and toxicity induced by MTX.
机译：甲氨蝶呤（MTX）被用作化学治疗剂，其抗氧化活性被用于治疗多种癌症。本研究旨在探讨银杏叶提取物（GLE）对MTX诱导的大鼠肝脏和肾脏毒性的修饰作用。总共60只雄性白化病大鼠被平均分为六组。第一组和第二组分别为对照组和GLE组，第三组为MTX大鼠组。第4组和第5组分别为联合治疗和后治疗的GLE MTX大鼠，第6组为MTX自治疗大鼠组。与对照组相比，MTX组的血清GPT，GOT，尿素，肌酐，尿酸和MDA水平显着升高，相反，MTX治疗组的肝脏抗氧化机制也显着降低，以GSH，过氧化氢酶，SOD为代表和总蛋白质。 GLE与MTX联用可改善MTX引起的肝肾损害。组织病理学和证据以及观察到的CD68免疫反应性支持MTX的有害作用和GLE对肝脏和肾脏毒性的改善作用。在整个治疗前后，GLE均具有多种抗MTX诱导的肝肾毒性的保护机制。我们可以得出结论，与GLE共同治疗具有有益的特性，并且可以减少MTX引起的肝肾损害和毒性。

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