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首页> 外文期刊>Journal of Clinical & Translational Endocrinology >Insulin resistance in Saudi postmenopausal women with and without metabolic syndrome and its association with vitamin D deficiency
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Insulin resistance in Saudi postmenopausal women with and without metabolic syndrome and its association with vitamin D deficiency

机译：患有和不患有代谢综合征的沙特绝经后妇女的胰岛素抵抗及其与维生素D缺乏的关系

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BackgroundThere is increasing interest in the non-skeletal effects of vitamin D and the relationship between vitamin D deficiency and chronic conditions such as diabetes mellitus. We aimed to investigate the relationship between surrogate indices of insulin resistance (IR), and vitamin D deficiency/insufficiency in postmenopausal Saudi women with and without metabolic syndrome.MethodsThe study population consisted of 300 postmenopausal women aged 46–88 years enrolled consecutively from women attending the Outpatient Clinics of King Abdulaziz University Hospital. Demographic, anthropometric, and biochemical parameters were recorded. Data were analyzed for women with and without metabolic syndrome.ResultsAbdominal obesity, IR, and hypovitaminosis D were highly prevalent within our population sample. Of the components used to define metabolic syndrome; waist circumference, serum triglycerides (TG), high density lipoprotein-cholesterol, and fasting blood glucose (FBG) were significantly related with all surrogate measures of IR. Significant inverse correlations were found between serum vitamin D and serum TG, FBG, and diastolic blood pressure, within the study cohort.ConclusionsThese observations suggest that hypovitaminosis D may be associated with the risk of developing metabolic syndrome. Interrelationships between IR, metabolic syndrome, and hypovitaminosis D are of particular interest in Saudi population, given the high prevalence of these conditions in this region.
机译：背景技术人们对维生素D的非骨骼作用以及维生素D缺乏与慢性病（如糖尿病）之间的关系越来越感兴趣。我们旨在调查绝经后沙特有无代谢综合征妇女的胰岛素抵抗（IR）替代指标与维生素D缺乏/不足之间的关系。方法研究人群由300名年龄在46-88岁的绝经后妇女组成，这些妇女从参加研究的妇女中连续入选。阿卜杜勒阿齐兹国王大学医院的门诊。记录人口统计，人体测量学和生化参数。分析有无代谢综合征的女性的数据。结果在我们的人群样本中，腹部肥胖，IR和维生素D缺乏症非常普遍。用于定义代谢综合征的成分;腰围，血清甘油三酸酯（TG），高密度脂蛋白胆固醇和空腹血糖（FBG）与所有IR替代指标均显着相关。在研究人群中，血清维生素D与血清TG，FBG和舒张压之间呈显着负相关。结论这些观察结果表明维生素D缺乏可能与发生代谢综合征的风险有关。鉴于沙特阿拉伯人群患病率高，IR，代谢综合征和维生素D缺乏症之间的相互关系特别令人关注。

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