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首页> 外文期刊>Journal of Contemporary Brachytherapy >Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space
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Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space

机译：经皮断层扫描指导的高剂量率间质近距离放射治疗在腹膜后间隙少转移性淋巴结转移中的疗效和安全性

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Purpose To assess efficacy, safety, and outcome of computed tomography (CT)-guided high-dose-rate (HDR) interstitial brachytherapy in patients with oligometastatic lymph node metastases of the retroperitoneal space. Material and methods 24 patients with a total of 47 retroperitoneal lymph node metastases from different primary tumors were treated with CT-guided interstitial brachytherapy using an sup192/supIr source (single fraction irradiation). Every three months after treatment, clinical and imaging follow-up were conducted to evaluate local control and safety. Results Median follow-up was 9.6 months (range, 2.9-39.0 months). Local tumor control rate was 95.7%. The median diameter of the gross tumor volume was 2.2 cm (range, 1-8.6 cm), treated with a median Dsub100/sub (minimal enclosing tumor dose) of 14.9 Gy (range, 4.5-20.6 Gy). One severe adverse event (grade three) was recorded. Cumulative median progression-free survival was 4.2 months (range, 1.4-23.7 months), and cumulative median overall survival after interstitial brachytherapy was 15.9 months (range, 3.8-39.0 months). Conclusions CT-guided HDR interstitial brachytherapy is a safe and feasible method for local ablation of oligometastatic lymph node metastases of the retroperitoneal space, and might provide a well-tolerated additional therapeutic option in the multidisciplinary management of selected patients.
机译：目的评估计算机断层扫描（CT）指导的高剂量率（HDR）间质近距离放射治疗在腹膜后间隙少转移淋巴结转移患者中的疗效，安全性和结果。材料和方法采用 192 Ir来源（单次照射），在CT引导下的间质近距离放射疗法治疗24例来自不同原发肿瘤的总共47个腹膜后腹淋巴结转移的患者。治疗后每三个月进行一次临床和影像学随访，以评估局部控制和安全性。结果中位随访时间为9.6个月（范围2.9-39.0个月）。局部肿瘤控制率为95.7％。用14.9 Gy（范围4.5-20.6 Gy）的中位D 100 （最小封闭肿瘤剂量）治疗的总肿瘤体积的中值直径为2.2 cm（范围为1-8.6 cm） 。记录了一次严重不良事件（三级）。累积中位无进展生存期为4.2个月（范围1.4-23.7个月），间质近距离放射治疗后的累积总生存期为15.9个月（范围3.8-39.0个月）。结论CT引导的HDR间质近距离放射治疗是局部消融腹膜后间隙少转移淋巴结转移的一种安全可行的方法，并且可能在选定患者的多学科治疗中提供耐受良好的其他治疗选择。

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