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首页> 外文期刊>Journal of immunology research. >Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization
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Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization

机译：橄榄花粉致敏性哮喘中肿瘤坏死因子-α，转化生长因子-β和白细胞介素10的多态性

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Sensitization to specific olive pollen-allergens (Ole e 2 and 10) has been correlated with a clinical pattern of asthma. This study analyzes the association between several polymorphims of TNFA (G-308A, C-857T, and C-1031T), IL10 (C-571A and A-1117G), and TGFB (C-509-T) and these sensitizations. These polymorphisms were genotyped by allelic discrimination, in olive pollen-allergic patients (phenotyped for specific Ole e 2 and 10 sensitizations) and healthy controls. Levels of serum-soluble cytokines were correlated with specific genotypes and clinical phenotypes. The results showed that heterozygous TGFB C-509T genotype, besides having the lowest sera TGF- levels, was significantly increased in olive pollen-allergic patients compared with controls. According specific sensitizations, CC genotype of IL10 C-571A could be a protective factor for Ole e 2 sensitization and mainly for asthmatic Ole e 2 sensitized patients compared with asthmatic non-Ole e 2 sensitized patients (OR 0.26, ). In contrast, heterozygous CA genotype was increased in Ole e 2 asthmatic subjects compared to asthmatic non-Ole e 2 sensitized patients. Lastly, heterozygous TNFA G-308A genotype was associated with Ole e 10 sensitization (OR 2.5, ). In conclusion, these results suggest a role of TGF-β1 in olive-pollen sensitization and TNF-α and IL-10 genotypes in the asthma induced by specific olive-pollen allergens.
机译：对特定橄榄花粉过敏原（Ole e 2和10）的致敏作用与哮喘的临床模式有关。这项研究分析了TNFA（G-308A，C-857T和C-1031T），IL10（C-571A和A-1117G）和TGFB（C-509-T）的几种多态性与这些致敏作用之间的关联。在橄榄花粉过敏的患者（针对特定的Ole e 2和10致敏性的表型）和健康对照组中，通过等位基因歧视对这些多态性进行基因分型。血清可溶性细胞因子水平与特定基因型和临床表型相关。结果表明，与对照相比，橄榄花粉过敏患者除血清TGF水平最低外，杂合的TGFB C-509T基因型显着增加。根据特定的致敏作用，与哮喘非Ole e 2致敏患者相比，IL10 C-571A的CC基因型可能是Ole e 2致敏的保护因子，主要是对哮喘Ole e 2致敏患者的保护因子（OR 0.26，）。相反，与哮喘非Ole e 2致敏患者相比，Ole e 2哮喘受试者中杂合CA基因型增加。最后，杂合的TNFA G-308A基因型与Ole e 10致敏相关（OR 2.5，）。总之，这些结果表明，TGF-β1在特定的橄榄花粉过敏原诱发的哮喘中，对橄榄花粉致敏以及TNF-α和IL-10基因型起作用。

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