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首页> 外文期刊>Journal of International Medical Research >The Efficacy, Safety and Pharmacokinetics of Intravenous Ciprofloxacin in Patients with Lower Respiratory Tract Infections
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The Efficacy, Safety and Pharmacokinetics of Intravenous Ciprofloxacin in Patients with Lower Respiratory Tract Infections

机译：环丙沙星对下呼吸道感染患者的疗效，安全性和药代动力学

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The efficacy and safety of intravenous ciprofloxacin 200 mg every 8 or 12 h and 300 mg every 12 h in treatment lasting 3 – 14 days were investigated in patients with lower respiratory tract bacterial infections. Patients presented with pneumonia, bronchiectasis with infection, previous pulmonary tuberculosis with infection and diffuse panbronchiolitis. Clinical efficacy was seen in six of eight patients, with apparent recovery in terms of chest radiographs, fever reduction and laboratory findings. Pharmacokinetic analysis in one patient treated with intravenous ciprofloxacin 300 mg showed that at 0.5 h after the first dose, ciprofloxacin serum and sputum concentrations were equivalent (2.45 ug/ml and 2.25 ug/ml, respectively). Adverse events were recorded in only two patients and involved a slight elevation in liver function tests and eosinophilia. This study indicates that intravenous ciprofloxacin is useful in the treatment of lower respiratory tract infections.
机译：在下呼吸道细菌感染的患者中，研究了静脉环丙沙星200 mg每8或12 h和300 mg每12 h持续3 – 14天的疗效和安全性。患者出现肺炎，支气管扩张合并感染，先前的肺结核合并感染和弥漫性全细支气管炎。 8例患者中有6例具有临床疗效，胸部X线照片，发烧减少和实验室检查结果均明显恢复。一名接受300 mg环丙沙星静脉注射治疗的患者的药代动力学分析表明，在首剂0.5小时后，环丙沙星血清和痰液浓度相当（分别为2.45 ug / ml和2.25 ug / ml）。仅两名患者记录了不良事件，其肝功能检查和嗜酸性粒细胞增多略有升高。该研究表明静脉内环丙沙星可用于治疗下呼吸道感染。

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