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首页> 外文期刊>Journal of International Medical Research >The Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Doxorubicin-induced Chronic Heart Failure in Rats
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The Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Doxorubicin-induced Chronic Heart Failure in Rats

机译：n-3多不饱和脂肪酸对阿霉素诱导的大鼠慢性心力衰竭的有益作用

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摘要

This study was designed to assess the effects of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) from fish oil on the response of doxorubicin-induced chronic heart failure in rats. Male Sprague–Dawley rats were treated daily for 8 weeks with normal saline or n-3 PUFA intragastrically after induction of myocardial injury by intraperitoneal injection of doxorubicin 2 mg/kg once weekly for 8 weeks. Cardiac function was assessed by echocardiography. The cytoprotective role of n-3 PUFA against doxorubicin-induced myocardial injury was demonstrated by light microscopy, and serum cytokines (tumour necrosis factor-α and interleukin-10) were analysed by enzyme-linked immunosorbent assay. Doxorubicin induced death, alterations in echocardiography parameters and histological damage, all of which are features that characterize heart failure. There were significant differences between the doxorubicin-induced heart failure group and the n-3 PUFA-treated group in terms of echocardiography parameters and cytokine changes. Thus, dietary supplementation with n-3 PUFA attenuated doxorubicin-induced cardiac dysfunction, an effect that might be associated with recovery from an imbalance of the cytokine network.
机译：这项研究旨在评估膳食补充鱼油中n-3多不饱和脂肪酸（PUFA）对阿霉素诱导的大鼠慢性心力衰竭的反应。雄性Sprague–Dawley大鼠在诱导心肌损伤后，每天通过腹膜内注射阿霉素2 mg / kg一次，每天一次，用生理盐水或n-3 PUFA灌胃8周，共8周。通过超声心动图评估心脏功能。通过光学显微镜证实了n-3 PUFA对阿霉素引起的心肌损伤的细胞保护作用，并通过酶联免疫吸附法分析了血清细胞因子（肿瘤坏死因子-α和白介素-10）。阿霉素导致死亡，超声心动图参数改变和组织学损害，所有这些都是心力衰竭的特征。在超声心动图参数和细胞因子变化方面，阿霉素诱导的心力衰竭组与n-3 PUFA治疗组之间存在显着差异。因此，膳食补充n-3 PUFA可减轻阿霉素诱导的心脏功能障碍，这种作用可能与细胞因子网络失衡的恢复有关。

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