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首页> 外文期刊>Journal of King Saud University >Promise of latanoprost and timolol loaded combinatorial nanosheet for therapeutic applications in glaucoma
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Promise of latanoprost and timolol loaded combinatorial nanosheet for therapeutic applications in glaucoma

机译：拉坦前列素和噻吗洛尔负载的组合纳米片在青光眼中的治疗应用前景

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摘要

To demonstrate a combinatorial drug loaded nanosheet made of alginate and chitosan which reduces intraocular pressure in a slow and sustained manner depicted by in-vivo studies. The combinatorial drugs loaded were latanoprost along with timolol and nanosheet was termed LATINA. LATINA was fabricated using spin coating procedure and characterized using scanning electron microscopy, atomic force microscopy, adhesive peel strength, burst and cytotoxicity tests. In-vitro studies of drugs were also performed. It was clearly seen that LATINA was stable, flexible, durable, biocompatible and biodegradable drug delivery system. The main advantage provided by the nanosheet technology is the properties which could be controlled by altering the thickness of the sheet. The slow and sustained drug release from LATINA ensured that the nanosheet may be renewed once weekly instead of daily as for other ophthalmic formulations for glaucoma. This also led to reduction of intra ocular pressure (IOP) of eye. LATINA was also found to be non-irritable to the cornea of eye.Hence, it may be safely concluded that with additional research, LATINA may prove to be the best option for drug delivery to the cornea.
机译：展示由藻酸盐和壳聚糖制成的负载组合药物的纳米片，该纳米片可以通过体内研究描述的缓慢而持续的方式降低眼内压。装载的组合药物是拉坦前列素和噻吗洛尔，纳米片称为LATINA。 LATINA使用旋涂程序制造，并使用扫描电子显微镜，原子力显微镜，胶粘剂剥离强度，破裂和细胞毒性测试进行表征。还进行了药物的体外研究。清楚地看到，LATINA是稳定，灵活，耐用，生物相容和可生物降解的药物输送系统。纳米片技术提供的主要优点是可以通过改变片的厚度来控制其性能。从LATINA缓慢而持续的药物释放确保纳米片可以每周更新一次，而不是像其他用于青光眼的眼科制剂那样每天更新一次。这也导致眼睛的眼内压（IOP）降低。还发现LATINA对眼睛的角膜没有刺激性。因此，可以肯定地得出结论，通过进一步的研究，LATINA可能被证明是将药物输送到角膜的最佳选择。

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