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首页> 外文期刊>Journal of medical bacteriology. >Evaluation of the Antibacterial Effects of Nickel Nanoparticles on Biofilm Production by Streptococcus mutans
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Evaluation of the Antibacterial Effects of Nickel Nanoparticles on Biofilm Production by Streptococcus mutans

机译：镍纳米粒子对变形链球菌生产生物膜的抗菌作用的评价。

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Background: Dental caries is a biofilm-dependent disease mainly causes by cariogenic bacteria that colonize dental surfaces, especially Streptococcus mutans. Nickel is a safe metal element which routinely used in dental compounds. The antibacterial and anti-biofilm effects of nickel nanoparticles (Ni-NPs) have been determined in limited studies, but the anti-biofilm effects of Ni-Nps on S. mutans have not been investigated before, so this study was aimed to investigate the anti-biofilm effects of Ni-NPs on S. mutans ATCC 35668.Methods: Biofilm formation by S. mutans ATCC 35668 was assayed by Microtiter Dish Biofilm Formation Assay and absorbance was measured by ELISA reader at 550 nm. The amounts of biofilm formation were also measured in the presence of 1, 01 and 0.01mg/mL concentrations of Ni- NPs by the same protocol and the mean amounts were compared between groups. Eight replicates were considered for each experiment. Data was statistically analyzed by SPSS16 software.Results: According to the statistical analysis, the amounts of biofilm formation were significantly reduced in the presence of all the tested concentrations of Ni-NPs.Conclusion: The current findings showed the potent anti-biofilm effects of Ni-NPs even in a concentration as low as 0.01 mg/ mL, so it is proposed for different applications in dentistry, considering its anti-biofilm effects. However, further studies
机译：背景：龋齿是一种生物膜依赖性疾病，主要由定植在牙齿表面的致龋细菌引起，尤其是变形链球菌。镍是一种安全的金属元素，通常用于牙科化合物中。镍纳米颗粒（Ni-NPs）的抗菌和抗生物膜作用已在有限的研究中确定，但是以前尚未研究Ni-Nps对变形链球菌的抗生物膜作用，因此本研究旨在研究方法：用微量滴定碟生物膜形成法检测变形链球菌ATCC 35668的生物膜形成，并用ELISA读数器在550 nm处测定吸光度。还通过相同方案在存在1、01和0.01mg / mL浓度的Ni-NP的情况下测量生物膜形成的量，并比较各组之间的平均值。每个实验考虑八次重复。结果：根据统计学分析，在所有测试浓度的Ni-NPs存在下，生物膜形成的数量均显着减少。结论：目前的研究结果表明，该酶具有很强的抗生物膜作用。 Ni-NPs的浓度甚至低至0.01 mg / mL，因此考虑到其抗生物膜作用，建议用于牙科的不同应用。但是，进一步的研究

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