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首页> 外文期刊>Journal of medical bacteriology. >Diffusely Adherent E. coli Burden in Low Socio-Economic Pediatric Population
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Diffusely Adherent E. coli Burden in Low Socio-Economic Pediatric Population

机译：低社会经济儿童人群的弥漫性粘附大肠杆菌负担

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Background: DAEC seems to be a neglected pathogen among diarrheagenic E. coli since its association with pediatric diarrhea is rarely reported. But, the emergence and spread of MDR diarrhea causing bacterial pathogens have become a global burden. This study investigated the prevalence of MDR DAEC among the Mizo pediatric diarrheal patients aged less than 5 years.Methods: A total of 334 E. coli isolates isolated from the fecal samples were subjected to multiplex PCR assays to categorize the pathotypes of diarrheagenic E. coli and subjected to antimicrobial sensitivity assay, phenotypic and genotypic ESBL assays (blaCTX-M-9, blaCTX-M-15, blaOXA and CMY-2). Results: Of 334 E. coli isolates, only 0.9% of the isolates were detected as DAEC, when compared with 0.9% and 1.2% of the isolates categorized as ETEC and EAEC from diarrheic samples and 0.6% of the EAEC also detected from the non-diarrheic samples. Among the isolates, 25%, 50% and 8.3% of the isolates were carrying the blaCTX-M-9, blaCTX-M-15 and CMY-2 respectively and 8.3% isolates from non-diarrheic samples also carried CMY-2.Conclusion: Though a low frequency of DAEC was observed in comparison to other pathotypes of DEC, majority of them being resistant to commonly used antibiotics and having a high MDR rate, which is a matter of concern to the public health. This pathotype could possibly a natural source for MDR spread among the other diarrheal pathogens of pediatric population.
机译：背景：DAEC似乎是腹泻性大肠杆菌中被忽略的病原体，因为很少报道与小儿腹泻有关。但是，引起细菌性病原体的耐多药性腹泻的出现和传播已成为全球性的负担。这项研究调查了5岁以下的Mizo小儿腹泻患者中MDR DAEC的患病率。并进行抗微生物药敏试验，表型和基因型ESBL试验（blaCTX-M-9，blaCTX-M-15，blaOXA和CMY-2）。结果：在334株大肠杆菌中，只有0.9％的分离物被检出为DAEC，而从腹泻样品中分为ETEC和EAEC的分离物分别为0.9％和1.2％，从非肠道分离物中也检出了0.6％的EAEC。 -腹泻样品。在这些分离株中，分别有25％，50％和8.3％的分离株携带blaCTX-M-9，blaCTX-M-15和CMY-2，非腹泻样品的分离株也有8.3％携带CMY-2。 ：尽管与其他病态的DEC相比，DAEC的发生率较低，但大多数对常用抗生素具有抗药性且MDR率高，这是公共卫生所关注的问题。这种病态可能是MDR在儿童人群的其他腹泻病原体中传播的自然来源。

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