• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of medical bacteriology. >Prevalence of Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Gene in Cutaneous Infections in the City of Isfahan
【24h】

Prevalence of Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Gene in Cutaneous Infections in the City of Isfahan

机译：在伊斯法罕市的皮肤感染中，耐甲氧西林的金黄色葡萄球菌携带潘顿-华伦特白蛋白基因的流行。

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Methicillin-Resistant Staphylococcus aureus (MRSA) is a major cause of Nosocomial and community infections that are becoming increasingly difficult to combat, because of emerging resistance to all classes of antibiotics. Moreover Panton-Valentine leukocidin (PVL) is an important virulence factor in S. aureus and causes white blood cell destruction, necrosis and accelerated apoptosis. The aim of this study was to determine the frequency of PVL-positive MRSA in cutaneous infections, for epidemiological purposes and also to determine antibiotic resistance of the isolates.Methods: Collectively, 56 isolates of S. aureus were obtained from Isfahan University of Medical sciences affiliated hospitals and confirmed with biochemical tests (coagulase, mannitol fermentation, and DNase). Then polymerase chain reaction (PCR) was used to detect pvl gene. Coagulase gene was used as internal control. The antibiotic susceptibility of all isolates to methicillin was determined using disk diffusion method.Results: Out of 56 isolates 14.3% were PVL positive that 37.5% were from abscess and 62.5% were from wound. Among all of these isolates 67.8% were MRSA and also 75% of PVL-positive isolates were MRSA.Conclusion: The prevalence of PVL positive MRSA in cutaneous isolates is high. Future works are necessary for a more complete understanding of distribution of these virulent isolates in nasal carriers to decrease the risk of infections
机译：背景：耐甲氧西林的金黄色葡萄球菌（MRSA）是引起医院和社区感染的主要原因，由于对所有抗生素的新出现的耐药性，它们正变得越来越难以抵抗。此外，Panton-Valentine leukocidin（PVL）是金黄色葡萄球菌的重要毒力因子，可引起白细胞破坏，坏死和加速凋亡。这项研究的目的是确定皮肤感染中PVL阳性MRSA的频率，用于流行病学目的以及确定分离株的抗生素耐药性。方法：从伊斯法罕医科大学获得了56株金黄色葡萄球菌分离株。附属医院并通过生化测试（凝固酶，甘露醇发酵和DNase）进行确认。然后用聚合酶链反应（PCR）检测pvl基因。凝固酶基因用作内部对照。结果：在56株病原菌中，有14.3％为PVL阳性，其中37.5％为脓肿，62.5％为伤口。在所有这些分离株中，MRSA占67.8％，PVL阳性分离株中有75％是MRSA。结论：皮肤分离物中PVL阳性MRSA的患病率很高。为了更全面地了解这些有毒分离物在鼻腔载体中的分布，以降低感染风险，未来的工作是必要的

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号