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首页> 外文期刊>Journal of medical bacteriology. >Current Antibiotic Resistance Trend in Clinical Isolates of Staphylococcus aureus from a Tertiary Care Hospital
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Current Antibiotic Resistance Trend in Clinical Isolates of Staphylococcus aureus from a Tertiary Care Hospital

机译：三级护理医院临床分离的金黄色葡萄球菌目前的耐药性趋势

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Background: Staphylococcus aureus (S. aureus) has remained always an important pathogen of common infections acquired in community and as well as serious nosocomial infections. With advent of penicillins and cephalosporins, infections could be effectively treated, but with the global emergence of Methicillin Resistant Staphylococcus aureus strains (MRSA) physicians were again left with limited treatment options. This scenario of increasing resistance is even more intense and challenging for developing countries like Pakistan. Hence with this background the study was carried out to establish the frequency of MRSA in clinical specimens and look into the available antibiotic treatment options.Methods: Samples of pus, blood, urine, body fluids and catheter tips submitted for culture in Microbiology department between August to September 2012, from outdoor and indoor adult patients of Pakistan Institute of Medical Sciences Islamabad, yielding growth of S. aureus were included in the study. After identification by standard methods, antibiotic susceptibility of the isolates was performed by Kirby Baeur disc diffusion method. The study was retrospective descriptive and observational.Results: Total 106 S. aureus were isolated. 45.3% of them were MRSA and majorities were from pus samples of hospitalized patients. All MRSA were 100% sensitive to vancomycin, whereas 87.5% to chloramphenicol. To rest of the non – beta lactam drugs, resistance of 80% or more was noted.Conclusion: S. aureus is a common clinical isolate from patients in this region of Pakistan and significant number were MRSA especially from hospitalized patients. Treatment options are limited to vancomycin and chloramphenicol.
机译：背景：金黄色葡萄球菌（S. aureus）一直是社区内常见感染以及严重的医院感染的重要病原体。随着青霉素和头孢菌素的出现，可以有效地治疗感染，但是随着耐甲氧西林金黄色葡萄球菌菌株（MRSA）的全球出现，医生再次受到了有限的治疗选择。对于巴基斯坦这样的发展中国家，增加抵抗的情况更加严峻且充满挑战。因此，在此背景下进行了这项研究，以确定临床标本中的MRSA频率，并探讨可用的抗生素治疗方法。方法：8月之间在微生物科提交用于培养的脓液，血液，尿液，体液和导管尖端样品到2012年9月，该研究包括了巴基斯坦伊斯兰堡医学研究所的室内和室外成年患者中产生金黄色葡萄球菌的生长。通过标准方法鉴定后，分离物的抗生素敏感性通过Kirby Baeur盘扩散法进行。结果：共分离出106株金黄色葡萄球菌。其中45.3％是MRSA，多数来自住院患者的脓液样本。所有MRSA对万古霉素敏感100％，而对氯霉素敏感87.5％。对于其余的非β-内酰胺药物，其耐药率达到80％或更高。结论：金黄色葡萄球菌是从巴基斯坦该地区患者中分离出的一种常见临床分离物，其中很大一部分是MRSA，尤其是住院患者。治疗选择仅限于万古霉素和氯霉素。

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