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首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >FUNCTIONAL MECHANISMS OF PROBIOTICS
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FUNCTIONAL MECHANISMS OF PROBIOTICS

机译：生物学的功能机制

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Probiotics are the live microorganisms which when ingested in adequate amounts confer health benefits. The strains most frequently used as probiotics include Lactic acid bacteria, bifidobacteria and yeast Saccharomyces boulardii. However, several other bacterial strains are being investigated for potential probiotic value viz. Enterococcus, Streptococcus, Bacillus, among others. Significant therapeutic potential of probiotics has been demonstrated in several in vitro studies and that involving animal models and humans. Despite intense focus on probiotics research the mechanisms responsible for health benefits are not yet completely understood. Several important mechanisms have been proposed such as improvement of gut epithelial barrier function, Immunomodulatory effects, degradation of toxin receptors, competition for nutrients, production of inhibitory substances, antiproliferative effects, blocking of adhesion sites and modulation of gut microbiota. Bacterial cell components such as DNA or peptidoglycan may also be involved in functional mechanism of probiotics. Effectiveness of a probiotic for potential application as prophylactic or treatment agent for certain ailment is determined by its ability to possess all or most of these characteristic features. The current article describes the general functional mechanisms of probiotics.
机译：益生菌是活的微生物，如果摄入足够的量，可以带来健康益处。最常用作益生菌的菌株包括乳酸菌，双歧杆菌和布拉氏酵母菌。但是，正在研究其他几种细菌菌株的潜在益生菌价值。肠球菌，链球菌，芽孢杆菌等。益生菌的巨大治疗潜力已在多项体外研究中得到证实，涉及动物模型和人类。尽管对益生菌的研究十分关注，但对健康有益的机制尚未完全了解。已经提出了几种重要的机制，例如改善肠上皮屏障功能，免疫调节作用，毒素受体的降解，竞争营养，抑制物质的产生，抗增殖作用，粘连位点的阻断和肠道菌群的调节。细菌细胞成分（例如DNA或肽聚糖）也可能参与益生菌的功能机制。益生菌作为某些疾病的预防剂或治疗剂的潜在用途的有效性取决于其具有所有或大多数这些特征的能力。本文介绍了益生菌的一般功能机制。

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