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首页> 外文期刊>Journal of Ayub Medical College >MEDICAL EXPULSIVE TREATMENT OF DISTAL URETERAL STONE USING TAMSULOSIN
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MEDICAL EXPULSIVE TREATMENT OF DISTAL URETERAL STONE USING TAMSULOSIN

机译：牛磺酸对药物治疗输尿管远端结石的研究

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Background: Many minimally invasive interventional techniques as well as expectant treatments exist for the management of lower ureteric calculi. This study was conducted to evaluate the efficacy of tamsulosin as an expulsive pharmacologic therapy for the treatment of distal ureteral stone. Methods: This randomized control trial included 100 patients over 18 years of age with stone Size ≤8mm in distal 1/3 of ureter. Patients were randomly assigned into two groups (A & B). Group A Patients were given Capsule Tamsulosin 0.4 mg, 1 daily up to 4 weeks while group B patients were? given placebo, 1 Capsule daily up to 4 weeks. The primary endpoint was expulsion rate. A written informed consent was taken from all the patients. Expulsion time, need for analgesics, need for hospitalization and drug side effects were secondary endpoints. Results: A total of 49 patients in group A and 48 patients in group B reported back, therefore 97 out of 100 patients were evaluated. Mean age of the patients was 36.34 years (range 18–57 years). ?Mean stone size was 5.78 mm (range 4–8 mm) in greatest dimension. A stone expulsion rate of 85.71% (42 patients) was noted in group A and 54.20% (26 patients) in group B.? Group A revealed a statistically significant advantage in term of stone expulsion rate ( p =0.032). Considering expulsion time in days group A showed statistically significant advantage ( p =0.015). Regarding age, sex, stone size and stone lateralization (right/left), there was no significant difference between the group A and B. No drug side effects were noted in both the groups. Conclusion: By using tamsulosin a higher stone expulsion rates can be achieved in a shorter time. More randomized control trials are required to establish tamsulosin as a standard medical expulsive treatment for small distal ureteric calculus. Keywords: Tamsulosin, expulsive pharmacologic therapy, ureteral stone
机译：背景：存在许多用于治疗输尿管下段结石的微创介入技术以及预期的治疗方法。进行这项研究以评估坦索罗辛作为输尿管远端输尿管结石的药物治疗的疗效。方法：该随机对照试验包括100名18岁以上，输尿管远端1/3处结石大小≤8mm的患者。将患者随机分为两组（A和B）。 A组患者接受坦索罗辛胶囊0.4 mg，每天1次，最多4周，而B组患者则给予？给定安慰剂，每天1粒，最多4周。主要终点是驱逐率。所有患者均签署了书面知情同意书。次要终点是驱逐时间，需要镇痛药，需要住院治疗和药物副作用。结果：A组共49例，B组48例，结果为100。患者的平均年龄为36.34岁（18-57岁）。 ？最大尺寸的平均石材尺寸为5.78毫米（范围4至8毫米）。 A组的石块排出率为85.71％（42例），B组为54.20％（26例）。 A组在结石排出率方面显示出统计学上的显着优势（p = 0.032）。考虑到A组中的驱逐时间，A组显示出统计学上的显着优势（p = 0.015）。关于年龄，性别，结石大小和结石偏侧（右/左），A组和B组之间无显着差异。两组均未观察到药物副作用。结论：使用坦索罗辛可以在较短的时间内获得更高的排石率。建立坦索罗辛作为远端输尿管小结石的标准医学排除治疗方法，还需要进行更多的随机对照试验。关键词：坦索罗辛，药物治疗，输尿管结石

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