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首页> 外文期刊>Journal of Molecular Psychiatry >Mass spectrometry as a tool for studying autism spectrum disorder
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Mass spectrometry as a tool for studying autism spectrum disorder

机译：质谱作为研究自闭症谱系障碍的工具

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摘要

Autism spectrum disorders (ASDs) are increasing in incidence but have an incompletely understood etiology. Tools for uncovering clues to the cause of ASDs and means for diagnoses are valuable to the field. Mass Spectrometry (MS) has been a useful method for evaluating differences between individuals with ASDs versus matched controls. Different biological substances can be evaluated using MS, including urine, blood, saliva, and hair. This technique has been used to evaluate relatively unsupported hypotheses based on introduction of exogenous factors, such as opiate and heavy metal excretion theories of ASDs. MS has also been used to support disturbances in serotonin-related molecules, which have been more consistently observed in ASDs. Serotonergic system markers, markers for oxidative stress, cholesterol system disturbances, peptide hypo-phosphorylation and methylation have been measured using MS in ASDs, although further analyses with larger numbers of subjects are needed (as well as consideration of behavioral data). Refinements in MS and data analysis are ongoing, allowing for the possibility that future studies examining body fluids and specimens from ASD subjects could continue to yield novel insights. This review summarizes MS investigations that have been conducted to study ASD to date and provides insight into future promising applications for this technique, with focus on proteomic studies.
机译：自闭症谱系障碍（ASD）的发病率正在增加，但病因学尚未完全了解。用于发现ASD病因的线索的工具以及用于诊断的手段对于该领域而言是有价值的。质谱（MS）已成为评估ASD个体与匹配对照之间差异的有用方法。可以使用MS评估不同的生物物质，包括尿液，血液，唾液和头发。该技术已用于根据外源因素（例如阿片类药物的鸦片和重金属排泄理论）的引入来评估相对不受支持的假设。 MS还被用于支持血清素相关分子的紊乱，这种现象在ASD中更为一致地观察到。尽管需要对大量受试者进行进一步分析（并考虑行为数据），但已使用MS在ASD中测量了血清素能系统标志物，氧化应激标志物，胆固醇系统紊乱标志物，肽低磷酸化和甲基化标志物。正在进行MS和数据分析方面的改进，这使得将来检查ASD受试者的体液和标本的研究可能继续产生新颖的见解。这篇综述总结了迄今为止为研究ASD而进行的MS研究，并深入研究了该技术的未来有希望的应用，重点是蛋白质组学研究。

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