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首页> 外文期刊>Journal of Molecular Psychiatry >Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
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Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features

机译：精神分裂症线粒体复合物I和III基因mRNA水平及其与临床特征的关系

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BackgroundThe etiology of schizophrenia is not precisely known; however, mitochondrial function and cerebral energy metabolism abnormalities were determined to be possible factors associated with the etiology of schizophrenia. Impaired mitochondrial function negatively affects neuronal plasticity, and can cause cognitive deficits and behavioral abnormalities observed during the clinical course of schizophrenia. The present study aimed to investigate the relationship between the clinical features of schizophrenia, and mitochondrial complex activation, based on measurement of mRNA levels in the NDUFV1 , NDUFV2 , NDUFS1 , and UQCR10 genes involved in the peripheral mitochondrial complex. MethodsThe study included 138 schizophrenia patients and 42 healthy controls. The schizophrenia group was divided into a chronic schizophrenia subgroup (n?=?84) and a first-episode schizophrenia subgroup (n?=?54). The symptoms profile and severity of disorder were evaluated using the Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), and Brief Psychiatric Rating Scale (BPRS). ResultsThe level of mRNA expression of NDUFV1 , NDUFV2 , and NDUFS1 was significantly higher in the schizophrenia group than in the control group. The mRNA level of NDUFV2 was positively correlated with BPRS and SAPS scores in the first-episode schizophrenia subgroup. ConclusionThe findings showed that there was a positive correlation between gene mRNA levels and psychotic symptomatology, especially positive symptoms. Our results suggest that mRNA levels of the NDUFV1 , NUDFV2 , and NDUFS1 genes of complex I of the mitochondrial electron transport chain might become a possible peripheral marker for the diagnosis of schizophrenia.
机译：背景精神分裂症的病因尚不清楚。然而，线粒体功能和脑能量代谢异常被确定为与精神分裂症病因相关的可能因素。线粒体功能受损会对神经元可塑性产生负面影响，并可能导致精神分裂症临床过程中观察到的认知缺陷和行为异常。本研究旨在研究精神分裂症的临床特征与线粒体复合物激活之间的关系，基于对参与外周线粒体复合物的NDUFV1，NDUFV2，NDUFS1和UQCR10基因中mRNA水平的测量。方法：该研究包括138位精神分裂症患者和42位健康对照者。精神分裂症组分为慢性精神分裂症亚组（n≥84）和首发精神分裂症亚组（n≥54）。使用阴性症状评估量表（SANS），阳性症状评估量表（SAPS）和简短精神病评定量表（BPRS）评估症状状况和疾病严重程度。结果精神分裂症组NDUFV1，NDUFV2和NDUFS1的mRNA表达水平明显高于对照组。在首发精神分裂症亚组中，NDUFV2的mRNA水平与BPRS和SAPS得分呈正相关。结论研究结果表明，基因mRNA水平与精神病症状特别是阳性症状呈正相关。我们的结果表明，线粒体电子传输链复合体I的NDUFV1，NUDFV2和NDUFS1基因的mRNA水平可能成为诊断精神分裂症的可能外周指标。

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