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首页> 外文期刊>Journal of Pharmaceutical Analysis >Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers
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Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

机译：大小均一的分子印迹聚合物对生物样品中痕量莱克多巴胺的分离和富集

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摘要

In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063mmol/g at 1mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.
机译：为了制备具有高识别能力的生物样品中痕量莱克多巴胺的固相萃取高容量填充材料，采用甲基丙烯酸作为多步溶胀和聚合方法，制备了大小均一的分子印迹聚合物（MIP）。功能性单体，乙二醇二甲基丙烯酸酯作为交联剂，甲苯作为成孔剂。用扫描电子显微镜和比表面积鉴定MIP的特征。进行了紫外光谱，傅里叶变换红外光谱，Scatchard分析和动力学研究，以解释MIP的特异性识别能力和结合过程。结果表明，与其他报道相比，本研究中合成的MIP除具有特异性识别能力外，还具有较高的吸附能力。在1mmol / L的莱克多巴胺浓度下，MIPs的吸附容量为0.063mmol / g，分布系数为1.70。所得的MIP可用作固相萃取材料，用于分离和富集生物样品中的痕量莱克多巴胺。

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