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首页> 外文期刊>Journal of the Canadian Academy of Child and Adolescent Psychiatry >Clinical Utility of Screening for Anxiety and Depression in Children with Tourette Syndrome
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Clinical Utility of Screening for Anxiety and Depression in Children with Tourette Syndrome

机译：抽动秽语综合征患儿焦虑和抑郁情绪筛查的临床效用

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Background Tourette syndrome (TS) is often co-morbid with attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Studies of TS, anxiety and depression have found variable results depending on study methodology and sample characteristics. Our aim was to examine the clinical utility of routine screening for anxiety and depression in children with TS. Methods Using a clinic-based sample, we evaluated the proportion of children with TS meeting diagnostic criteria for ADHD, OCD, generalized anxiety disorder (GAD), separation anxiety disorder (SAD), and major depressive disorder (MDD); the frequency of above average anxiety and depressive symptoms using the Multidimensional Anxiety Scale for Children (MASC) and the Children’s Depression Inventory (CDI); and the association between diagnoses and symptom severity. Results One hundred twenty six children were included (mean age 10.7 years). The most common comorbid disorder was ADHD (37%), followed by GAD (21%), OCD (10%), MDD (2%) and SAD (2%). On the MASC, the separation anxiety/panic subscale score was higher than all other subscale scores (p<0.0001). Clinically significant anxiety symptoms were present in 20% of the sample based on the MASC Anxiety Disorders Index, while 6% were identified as potentially clinically depressed based on the CDI Total Score. Yale Global Tic Severity Scale scores were positively correlated with total scores on the MASC (r=0.22, p=0.03) and CDI (r=0.37, p=0.0002). Conclusions Routine screening children with TS for anxiety is warranted given the rate of comorbidity. Screening for depression in TS will have a higher yield in adolescents, adults, and children with more severe tics.
机译：背景Tourette综合征（TS）通常与注意力缺陷多动障碍（ADHD）和强迫症（OCD）并存。根据研究方法和样本特征，对TS，焦虑和抑郁的研究发现了可变的结果。我们的目的是检查常规筛查TS儿童焦虑和抑郁的临床效用。方法采用临床样本，评估符合ADHD，OCD，广泛性焦虑症（GAD），分离性焦虑症（SAD）和重度抑郁症（MDD）诊断标准的TS患儿比例;使用儿童多维焦虑量表（MASC）和儿童抑郁量表（CDI）评估高于平均水平的焦虑和抑郁症状的频率;以及诊断与症状严重程度之间的关联。结果共纳入126名儿童（平均年龄10.7岁）。最常见的合并症是ADHD（37％），其次是GAD（21％），OCD（10％），MDD（2％）和SAD（2％）。在MASC上，分离焦虑/惊恐分量表得分高于所有其他分量表得分（p <0.0001）。根据MASC焦虑症指数，有20％的样本具有临床上显着的焦虑症状，而根据CDI总分，有6％的样本被认为具有潜在的临床抑郁症。耶鲁全球Tic严重度量表得分与MASC（r = 0.22，p = 0.03）和CDI（r = 0.37，p = 0.0002）的总得分呈正相关。结论考虑到合并症的发生率，有必要常规筛查TS患儿的焦虑症。在青少年，成人和抽动症较严重的儿童中筛查TS抑郁症的几率更高。

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