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首页> 外文期刊>Journal of Young Pharmacists >Development of Fast Dissolving Tablets of Nisoldipine by Solid Dispersion Technology using Poloxamer 407 and Poloxamer 188
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Development of Fast Dissolving Tablets of Nisoldipine by Solid Dispersion Technology using Poloxamer 407 and Poloxamer 188

机译：使用泊洛沙姆407和泊洛沙姆188固体分散技术开发尼索地平速溶片

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Objective: The aim of the present study is to design oral fast-release tablets of nisoldipine and to optimize the drug dissolution profile by modifying the carrier concentration. Poloxamer 407 and Poloxamer 188 were selected as carriers for preparing the solid dispersion (SD) by solvent evaporation method with different drug polymer ratios. Methods: The prepared solid dispersions were analyzed for physical state, drug:carrier interactions by Xray diffraction, infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. Results: The dissolution studies revealed that all solid dispersions showed increased dissolution rate whencompared to pure nisoldipine. Among the two polymers used, poloxamer 407(P 407) was found to be better than poloxamer 188(P 188) in the enhancement of dissolution efficiency. The tablets were formulated using solid dispersion of nisoldipine containing poloxamer 407 as carrier. Conclusion: The results exhibited that poloxamer 407 SD based tablets gave a significantly higher release of nisoldipine when compared with control tablets. Infrared spectral studies showed that there was no interaction between thenisoldipine and its formulation with different carriers used in the preparation of solid dispersions. X-ray diffraction studies revealed that the degree of crystallinity of nisoldipine decreased when the concentration of carriers increased, which showed that the drug is in amorphous nature.
机译：目的：本研究的目的是设计尼索地平口服速释片，并通过改变载体浓度来优化药物溶出度。选择泊洛沙姆407和泊洛沙姆188作为载体，通过溶剂蒸发法以不同的药物聚合物比例制备固体分散体（SD）。方法：通过X射线衍射，红外光谱，差示扫描量热法和扫描电子显微镜对制备的固体分散体的物理状态，药物：载体相互作用进行分析。结果：溶出度研究表明，与纯尼索地平相比，所有固体分散体均显示出增加的溶出速率。在使用的两种聚合物中，发现泊洛沙姆407（P 407）在提高溶解效率方面优于泊洛沙姆188（P 188）。使用含有泊洛沙姆407作为载体的尼索地平固体分散体配制片剂。结论：结果显示，与对照片剂相比，基于泊洛沙姆407 SD的片剂可明显提高尼索地平的释放。红外光谱研究表明，尼索地平及其制剂与用于制备固体分散体的不同载体之间没有相互作用。 X射线衍射研究表明，尼古地平的结晶度随载体浓度的增加而降低，表明该药物为无定形性质。

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