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首页> 外文期刊>Journal of Young Pharmacists >Characterization of Microcrystalline Cellulose Obtained from Enzymatic Hydrolysis of Alpha-Cellulose and its Application
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Characterization of Microcrystalline Cellulose Obtained from Enzymatic Hydrolysis of Alpha-Cellulose and its Application

机译：酶水解α-纤维素获得微晶纤维素的表征及其应用

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Objective: This study was aimed to prepare microcrystalline cellulose (MCC) powder from α-cellulose of water hyacinth, find its characteristics and purity compared to Avicel PH 101 as reference and its tablets evaluation. Water hyacinth has great potential as raw materials of MCC fine due to its highest content of cellulose. Method: MCC was obtained by enzymatic hydrolysis with cellulase enzymes. The prepared MCC powder was identified by infrared spectroscopy and melting point, then was characterized over several parameters. Then, the MCC was applied to a tablet formulation and evaluated for its weight variation, thickness and diameter, hardness, friability and disintegration time. Results: The identity obtained from infrared spectrum was quite similar with reference and the melting point charred between 247-250°C. The powder was moderately fine, odorless, tasteless and yellowish compared to the reference. The characteristics were obtained, including particle size distribution for 741 nm, pH ± 7.49, ash contents ± 0.203%, moisture content ± 3.685%, loss on drying ± 3.8741% also the density, flow rate and angle of repose met the requirements. The results of Scanning Electron Microscope showed similar morphology of crystalline with reference and the diffractogram patterns showed crystalline form type 2. Tablets were prepared by dry granulation method and the weight variation, thickness and diameters and disintegration time evaluations met the requirements. Conclusion: The MCC obtained has quite similar identities and characteristics with commercial available one (Avicel PH 101) and can be used as an excipient.
机译：目的：本研究旨在从风信子的α-纤维素制备微晶纤维素（MCC）粉末，并以Avicel PH 101为参考品，比较其特性和纯度，并对片剂进行评价。水葫芦由于其纤维素含量最高，具有作为MCC细粉原料的巨大潜力。方法：通过纤维素酶酶促水解获得MCC。通过红外光谱和熔点鉴定所制备的MCC粉末，然后通过几个参数对其进行表征。然后，将MCC应用于片剂制剂，并评估其重量变化，厚度和直径，硬度，易碎性和崩解时间。结果：从红外光谱获得的身份与参考非常相似，熔点在247-250°C之间烧焦。与参考相比，该粉末适度细，无味，无味和微黄色。获得的特性包括741 nm的粒径分布，pH±7.49，灰分±0.203％，水分含量±3.685％，干燥失重±3.8741％，密度，流速和休止角均满足要求。扫描电子显微镜的结果显示晶体与参照物相似，并且衍射图谱显示为晶型2。通过干法制粒法制备片剂，其重量变化，厚度和直径以及崩解时间评估均符合要求。结论：获得的MCC具有与市售MCC（Avicel PH 101）相似的特性和特征，可以用作赋形剂。

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