Design and microwave-assisted synthesis of 1,3,4-oxadiazole derivatives for analgesic and anti-inflammatory activity

CR Biju; K Ilango; Manju Prathap; K Rekha

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Design and microwave-assisted synthesis of 1,3,4-oxadiazole derivatives for analgesic and anti-inflammatory activity

机译：1,3,4-恶二唑衍生物的设计和微波辅助镇痛和抗炎作用

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1,3,4-Oxadizoles form a biologically important group of compounds having activities like analgesic, anti-inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating and mono amino oxidase inhibition. This research has focused on the incorporation of the oxadiazole moiety into isoniazid because of their versatile biological action, to get 2-aryl-5-(4-pyridyl)-1,3,4-oxadiazole to explore the possibilities of some altered biological action. 1,3,4-Oxadiazole derivatives were synthesized by microwave-assisted synthesis and screened for their analgesic, anti-inflammatory activities. The synthesized compounds were characterized by Melting point, Thin layer chromatographyInfra red, Nuclear magnetic resonance spectroscopy, etc. Almost all the synthesized compounds possessed good activity as compared to the standard.

机译：1,3,4-恶二唑形成一组生物学上重要的化合物，其活性如止痛药，抗炎药，杀菌剂，抗真菌药，抗惊厥药，精神药物，植物生长调节剂和单氨基氧化酶抑制剂。这项研究着重于将恶二唑部分因其多功能的生物作用而并入异烟肼中，从而获得2-芳基-5-（4-吡啶基）-1,3,4-恶二唑，以探索某些改变的生物作用的可能性。 1,3,4-恶二唑衍生物是通过微波辅助合成方法合成的，并对其镇痛，抗炎活性进行了筛选。通过熔点，薄层色谱，红外，核磁共振波谱等方法对合成的化合物进行了表征。与标准品相比，几乎所有合成的化合物都具有良好的活性。

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《Journal of Young Pharmacists》 |2012年第1期|共5页
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CR Biju; K Ilango; Manju Prathap; K Rekha;
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机译：1,3,4-恶二唑衍生物的镇痛和抗炎活性设计与微波合成

Design and microwave-assisted synthesis of 1,3,4-oxadiazole derivatives for analgesic and anti-inflammatory activity

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