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首页> 外文期刊>Journal of Young Pharmacists >Optimization of Process Parameters for Development of Camptothecin Loaded Poly (Methacylic Acid-Co-Methyl Methyacrylate) Nanoparticles Using Plackett-Burman Factorial Design Methodology
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Optimization of Process Parameters for Development of Camptothecin Loaded Poly (Methacylic Acid-Co-Methyl Methyacrylate) Nanoparticles Using Plackett-Burman Factorial Design Methodology

机译：Plackett-Burman因子设计方法优化喜树碱负载聚甲基丙烯酸-甲基丙烯酸甲酯共​​聚物纳米粒子的工艺参数

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Objective: The aim of the present study was to develop Camptothecin loaded poly (methacylic acid-co-methyl methyacrylate) nanoparticles and to optimize the process parameters for the preparation of polymeric nanoparticles using Plackett-Burman factorial design. The relationship between design factor and experimental data was evaluated. Method: In this study, Camptothecin loaded poly (methacylic acid-co-methyl methyacrylate) nanoparticles were prepared by nanoprecipitation method. The prepared nanoparticles were optimized using Plackett-Burman method. Critical formulation variables were optimized in this study in terms of their corresponding effects on the preparation of nanoparticles. The characterization of the optimized nanoformulations with respect to particle size distribution, particle morphology were carried out using malvern instrument and transmission electron microscope (TEM). Results: Factorial design results have shown that (a) Except, β-cyclodextrin concentration, poloxamer concentration and the process all other parameters significantly influenced the average particle size; (b) Except, stirring time, stirring speed and stirring mode all other process parameters significantly influence the particle size uniformity; (c) Except, volume of organic phase and stirring speed all other process parameters significantly influence the surface area. Conclusion: The average particle size, particle size uniformity and surface area of the optimized formulation were found to be 99.29 nm, 0.242 and 65.2 m2g-1 respectively. Surface morphology examination has shown that the prepared nanoparticles were spherical in shape. Characterization of optimized formulation provided by evaluation of experimental data showed no significant difference between observed and predicted value.
机译：目的：本研究的目的是开发载有喜树碱的聚（甲基丙烯酸-甲基丙烯酸甲酯）共聚物纳米粒子，并利用Plackett-Burman因子设计优化用于制备聚合物纳米粒子的工艺参数。设计系数和实验数据之间的关系进行了评估。方法：在本研究中，通过纳米沉淀法制备了喜树碱负载的聚（甲基丙烯酸-甲基丙烯酸甲酯）纳米颗粒。使用Plackett-Burman方法优化了制备的纳米颗粒。在这项研究中，针对关键配方变量对纳米颗粒制备的相应影响进行了优化。使用马尔文仪器和透射电子显微镜（TEM）对优化的纳米制剂的粒度分布，颗粒形态进行了表征。结果：析因设计结果表明：（a）除β-环糊精浓度，泊洛沙姆浓度和工艺参数外，其他所有参数均显着影响平均粒径; （b）除搅拌时间，搅拌速度和搅拌方式外，所有其他工艺参数均会显着影响粒度均匀性; （c）除了有机相的体积和搅拌速度外，所有其他工艺参数都会显着影响表面积。结论：优化配方的平均粒径为99.29 nm，粒径均匀度为0.242，表面积为65.2 m 2 g -1 。表面形态学检查显示所制备的纳米颗粒为球形。通过对实验数据的评估提供的优化配方的表征显示，观察值与预测值之间无显着差异。

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