• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Translational Medicine >Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals
【24h】

Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals

机译：阿拉伯人维生素D水平的遗传变异和生活方式决定因素调查

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have been conducted in European populations. Here we aimed to identify common genetic variants that affect vitamin D concentrations in individuals of self-reported Arab ethnicity. The study included 1151 Arab subjects living in Kuwait. Common variants of single-nucleotide polymorphisms and genes previously associated with vitamin D levels, such as GC, PDE3B, CYP2R1, and NADSYN1, were genotyped. Raw vitamin D level data were corrected for age, body mass index, and sex and then normalized. Regression tree analyses were performed to identify the impact of genetic variants on vitamin D levels. Compared with other gene variants, the GC gene variants exhibited the greatest impact on vitamin D levels in our study population, of which rs2298850 had the lowest p value (0.003). Individuals homozygous for the derived allele C had lower vitamin D levels. Analyses of the interaction between the number of years for which the subjects had lived in Kuwait and genetic variation in the GC gene showed that those with the CC genotype of rs2298850 who had lived in Kuwait for 51?years had higher vitamin D levels (mean 28?ng/ml) regardless of the genotype of their GC gene. The GC gene may play a major role in determining vitamin D levels in Arab populations.
机译：循环中的25-羟基维生素D [25（OH）D]的浓度差异与广泛的健康结果有关。但是，大多数影响25（OH）D水平的遗传变异的研究都是在欧洲人群中进行的。在这里，我们旨在确定影响自我报告的阿拉伯族裔个体中维生素D浓度的常见遗传变异。该研究包括居住在科威特的1151名阿拉伯受试者。对单核苷酸多态性的常见变异和先前与维生素D水平相关的基因进行了基因分型，例如GC，PDE3B，CYP2R1和NADSYN1。原始维生素D水平数据已针对年龄，体重指数和性别进行了校正，然后进行了标准化。进行回归树分析以鉴定遗传变异对维生素D水平的影响。与其他基因变体相比，GC基因变体在我们研究的人群中对维生素D水平的影响最大，其中rs2298850的p值最低（0.003）。衍生的等位基因C纯合的个体维生素D水平较低。对受试者在科威特生活的年数与GC基因遗传变异之间相互作用的分析表明，在科威特生活了51年的CC基因型为rs2298850的人维生素D水平较高（平均值28 （μng/ ml），无论其GC基因的基因型如何。 GC基因可能在确定阿拉伯人群的维生素D水平中起主要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号