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首页> 外文期刊>Jundishapur Journal of Microbiology >Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated from Clinical Samples
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Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated from Clinical Samples

机译：从临床样本中分离出念珠菌的多中心鉴定和抗真菌药敏模式

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Background: Invasive fungal infections without proper treatment could lead to high mortality rate, especially in immunocompromised patients. Candida species distribution and drug susceptibility patterns vary in different areas. Understanding the etiologic agents and drug susceptibility patterns in each region are required for the best management of patients with Candida infections. Objectives: The aim of this study was to identify Candida species isolated from clinical samples of six university hospitals in Iran and detect their susceptibility patterns to seven antifungal agents. Methods: Clinical samples from patients with fungal infections were cultured on Sabouraud dextrose agar. Isolated yeasts were identified by API 20C AUX kit, according to the manufacturer’s instructions. Drug susceptibility patterns to amphotericin B, caspofungin, voriconazole, fluconazole, posaconazole, itraconazole and ketoconazole were determined, according to CLSI M27-A3 and S4. Results: In total, 428 species of Candida were isolated from clinical samples (1950 samples). Most isolated species were Candida albicans, followed by C. tropicalis, C. parapsilosis, C. kefyr, C. famata, C. glabrata, C. krusei, C. dubliniensis, C. guilliermondii and C. lusitaniae. Sensitivity rate of C. albicans to amphotericin B, caspofungin, voriconazole, fluconazole, and itraconazole was 96.6%, 99.5%, 88.6%, 90.6%, and 52% with MIC90 values equal to 0.25 μg/mL, 0.125 μg/mL, 0.125 μg/mL, 2 μg/mL, and 1 μg/mL, respectively. The MIC 90 values for ketoconazole and posaconazole were 0.125 μg/mL and 0.064 μg/mL, respectively. Different sensitivity to antifungal agents was present in non-albicans Candida species especially in C. krusei, C. glabrata, and C. tropicalis. Conclusions: According to this study, C. albicans is the most prevalent etiologic agent in infected patients and caspofungin is the most effective antifungal agent. Knowledge about etiologic agents and their susceptibility patterns in each region is helpful for successful treatment of the patients
机译：背景：未经适当治疗的侵袭性真菌感染可导致高死亡率，尤其是在免疫功能低下的患者中。念珠菌的物种分布和药物敏感性模式在不同地区有所不同。需要了解每个地区的病原体和药物敏感性模式，才能更好地管理念珠菌感染患者。目的：本研究的目的是鉴定从伊朗六所大学医院临床样本中分离出的念珠菌，并检测其对七种抗真菌药的敏感性。方法：将真菌感染患者的临床样品在Sabouraud葡萄糖琼脂上培养。根据制造商的说明，通过API 20C AUX试剂盒鉴定了分离的酵母。根据CLSI M27-A3和S4，确定了对两性霉素B，卡泊芬净，伏立康唑，氟康唑，泊沙康唑，伊曲康唑和酮康唑的药敏模式。结果：共从临床样本（1950个样本）中分离出428种念珠菌。多数分离的物种为白色念珠菌，其次为热带念珠菌，副念珠菌，开菲氏念珠菌，法氏念珠菌，glabrata念珠菌，克鲁赛氏菌，杜比利尼梭菌，guilliermondii念珠菌和lusitaniae念珠菌。白色念珠菌对两性霉素B，卡泊芬净，伏立康唑，氟康唑和伊曲康唑的敏感性为96.6％，99.5％，88.6％，90.6％和52％，MIC90值分别为0.25μg/ mL，0.125μg/ mL，0.125 μg/ mL，2μg/ mL和1μg/ mL。酮康唑和泊沙康唑的MIC 90值分别为0.125μg/ mL和0.064μg/ mL。非白色念珠菌物种对抗真菌剂的敏感性不同，尤其是在克鲁氏梭菌，光滑梭菌和热带梭菌中。结论：根据这项研究，白色念珠菌是感染患者中最流行的病原体，卡泊芬净是最有效的抗真菌剂。了解每个地区的病原体及其易感性有助于成功治疗患者

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