Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore

CY Shi; TW Phang; Y Lin; A Wee; B Li; HP Lee; CN Ong

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Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore

机译：在新加坡华人的肝细胞癌中，p53基因的249号密码子突变是罕见的事件

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The present study characterised p53 mutations in 44 hepatocellular carcinomas (HCCs) from Chinese patients residing in a high-incidence area. Twelve point mutations (27%) were detected in tumour tissues using single-strand conformation polymorphism analysis followed by direct DNA sequencing. Remarkably, no mutations were observed at codon 249. This is in contrast to HCCs from other high HCC incidence areas with endemic aflatoxin exposures, in which codon 249 is a mutational hot spot. It is therefore suggested that risk factors other than dietary exposure to aflatoxin may contribute to the high HCC incidence in Singapore.

机译：本研究对来自高发地区的中国患者的44例肝细胞癌（HCC）中的p53突变进行了表征。使用单链构象多态性分析，然后直接进行DNA测序，在肿瘤组织中检测到十二个点突变（27％）。值得注意的是，在249位密码子上未观察到突变。这与来自其他高HCC发生地区的地方性黄曲霉毒素暴露的HCC，其中249位密码子是突变热点。因此建议在新加坡，除了饮食中摄入黄曲霉毒素以外的其他风险因素也可能导致高HCC发生。

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《British Journal of Cancer》 |1995年第1期|共4页
作者
CY Shi; TW Phang; Y Lin; A Wee; B Li; HP Lee; CN Ong;
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中图分类肿瘤学;
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1. Mutations at codon 249 of p53 gene in human hepatocellular carcinomas from Tongan, China. [J] . Yang M, Zhou H, Kong RY, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1997,第1期

机译：中国汤加人肝细胞癌中p53基因第249位密码子的突变。
2. Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p53 gene in hepatocellular carcinoma among Guangxi population, China. [J] . Long XD, Ma Y, Huang HD, Molecular Carcinogenesis . 2008,第4期

机译：广西人群肝细胞癌中XRCC1的多态性与p53基因第249位密码子的突变频率。
3. Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China [J] . Xing-Hua Huang, Lu-Hong Sun, Dong-Dong Lu, World Journal of Gastroenterology . 2003,第4期

机译：血浆DNA p53基因第7外显子的249位密码子突变：可能是启东危险地区肝细胞癌的早期诊断新指标
4. Aflatoxin and p53 gene mutation in hepatocellular carcinoma [C] . Deng Zhuolin, Ma Yun Proceedings of the Fourth China-Jpan international congress of mycology . 1998

机译：黄曲霉毒素和p53基因突变在肝细胞癌中
5. Functional characterization of novel HBV subgenotypes/mutations associated with increased risk for hepatocellular carcinoma (HCC) [D] . Dong, Qingming 2009

机译：与肝细胞癌（HCC）风险增加相关的新型HBV亚型/突变的功能表征
6. Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore. [O] . C. Y. Shi, T. W. Phang, Y. Lin, 1995

机译：在新加坡华人的肝细胞癌中p53基因的249位密码子突变是罕见的事件。
7. Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore. [O] . Shi, C. Y., Phang, T. W., Lin, Y., 1995

机译：在新加坡华人的肝细胞癌中，p53基因的249位密码子突变是罕见的事件。

Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore

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