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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Plasma Homocysteine Is Weakly Correlated with Plasma Endothelin and von Willebrand Factor but not with Endothelium-dependent Vasodilatation in Healthy Postmenopausal Women
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Plasma Homocysteine Is Weakly Correlated with Plasma Endothelin and von Willebrand Factor but not with Endothelium-dependent Vasodilatation in Healthy Postmenopausal Women

机译：血浆同型半胱氨酸与健康绝经后妇女的血浆内皮素和血管性血友病因子弱相关，但与内皮依赖性血管舒张无关。

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Background: Hyperhomocysteinemia is an independent cardiovascular risk factor, possibly through the induction of endothelial dysfunction. The postmenopausal state is associated with increased plasma homocysteine. We examined whether increased homocysteine is associated with impaired endothelial function.Methods: Sixty-three hysterectomized but otherwise healthy postmenopausal women (54.8 ± 3.5 years) participated in this study. Fasting total plasma homocysteine (tHcy) was measured as free plus protein-bound homocysteine. Endothelial function was assessed by measuring plasma concentrations of the endothelium-derived proteins endothelin (ET), von Willebrand factor (vWF), and plasminogen activator inhibitor type 1 (PAI-1) as well as brachial artery flow-mediated, endothelium-dependent vasodilatation (FMD).Results: Plasma tHcy was 9.6 ± 2.5 μmol/L. After adjustment for possible confounders, a 1 μmol/L increase in tHcy was associated with an increase in ET of 0.08 ng/L ( P = 0.045) and an increase in vWF of 4.2% ( P = 0.05). No statistically significant association was present between tHcy and PAI-1 or FMD.Conclusions: Increased fasting homocysteine in postmenopausal women may impair some aspects of endothelial function. It is of clinical interest to study whether homocysteine lowering can improve endothelial function and thus cardiovascular morbidity and mortality in postmenopausal women.
机译：背景：高同型半胱氨酸血症是独立的心血管危险因素，可能是通过诱导内皮功能障碍引起的。绝经后状态与血浆同型半胱氨酸增加有关。我们检查了同型半胱氨酸水平升高是否与内皮功能受损有关。方法：63名经子宫切除但健康的绝经后妇女（54.8±3.5岁）参加了这项研究。空腹总血浆同型半胱氨酸（tHcy）测定为游离加结合蛋白的同型半胱氨酸。通过测量血浆中内皮源蛋白（ET），von Willebrand因子（vWF）和纤溶酶原激活物抑制剂1型（PAI-1）以及肱动脉血流介导的内皮依赖性血管舒张的血浆浓度来评估内皮功能结果：血浆tHcy为9.6±2.5μmol/ L。调整可能的混杂因素后，tHcy增加1μmol/ L可使ET增加0.08 ng / L（P = 0.045）和vWF增加4.2％（P = 0.05）。结论：tHcy与PAI-1或FMD之间无统计学意义的相关性。结论：绝经后妇女的空腹高半胱氨酸水平升高可能会损害内皮功能的某些方面。研究降低同型半胱氨酸是否可以改善绝经后妇女的内皮功能，从而改善心血管疾病的发病率和死亡率，具有临床意义。

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