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首页> 外文期刊>Applied and Environmental Microbiology >Conversion of a new metabolite to aflatoxin B2 by Aspergillus parasiticus.
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Conversion of a new metabolite to aflatoxin B2 by Aspergillus parasiticus.

机译：寄生曲霉将新的代谢物转化为黄曲霉毒素B2。

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摘要

A new metabolite which could be converted to aflatoxin (AF) B2 was detected during cofermentation analysis of two nonaflatoxigenic strains (SRRC 2043 and SRRC 163) of Aspergillus parasiticus. SRRC 2043, which accumulates the xanthone O-methylsterigmatocystin (OMST), a late precursor in the AFB1 pathway, was observed to accumulate another chemically related compound (HOMST; molecular weight, 356); SRRC 163 is blocked early in the pathway and accumulates averantin. During cofermentation of the two strains, levels of OMST and HOMST were observed to be greatly reduced in the culture, with simultaneous production of AFB1, AFB2, and AFG1. Intact cells of SRRC 163 were able to convert pure OMST or its precursor, sterigmatocystin, to AFB1 and AFG1 without AFB2 accumulation; the same cells converted isolated HOMST to AFB2 with no AFB1 or AFG1 production. The results indicate that AFB2 is produced from a separate branch in the AF biosynthetic pathway than are AFB1 and AFG1; AFB2 arises from HOMST, and AFB1 and AFG1 arise from sterigmatocystin and OMST.
机译：在两个寄生曲霉的非黄曲霉毒素菌株（SRRC 2043和SRRC 163）的共同发酵分析过程中检测到一种新的代谢物，该代谢物可以转化为黄曲霉毒素（AF）B2。观察到SRRC 2043积累了AFB1途径中较晚的前体黄酮O-甲基甾体藻毒素（OMST），它积累了另一种化学相关的化合物（HOMST;分子量356）。 SRRC 163在该途径的早期被阻断并积累了阿维那汀。在两个菌株的共同发酵过程中，观察到培养物中OMST和HOMST的水平大大降低，同时产生了AFB1，AFB2和AFG1。完整的SRRC 163细胞能够将纯的OMST或其前体stercysttocystin转换为AFB1和AFG1，而不会积聚AFB2。同样的细胞将分离的HOMST转化为AFB2，而没有产生AFB1或AFG1。结果表明，AFB2是由AF生物合成途径中一个独立的分支产生的，而不是AFB1和AFG1。 AFB2来源于HOMST，AFB1和AFG1来源于葡萄球菌毒素和OMST。

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