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Inhibition of Neisseria gonorrhoeae by a Factor Produced by Candida albicans

机译：白色念珠菌产生的因子对淋病奈瑟菌的抑制作用

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When Candida albicans is present on Transgrow specimens, Neisseria gonorrhoeae is detected less frequently or else can be seen in Gram stains but cannot be readily cultured. When C. albicans and N. gonorrhoeae are grown together on Transgrow, the gonococcal cells die off much more readily than N. gonorrhoeae grown on Transgrow alone. By use of a cross-streaking technique on agar plates, it has been demonstrated that C. albicans produces a soluble substance inhibitory to N. gonorrhoeae, although not to other microorganisms tested. Preliminary results indicate that this inhibitory factor can be extracted by the use of tertiary butanol. Since approximately one-third of the Transgrow specimens with growth contains yeasts, of which C. albicans is by far the most frequent, this factor presents an important complication in the diagnosis of gonorrhea in women.
机译：当Transgrow标本上存在白色念珠菌时，淋病奈瑟菌的检出频率降低，或者在革兰氏染色中可见，但不易培养。当白色念珠菌和淋病奈瑟氏球菌在Transgrow上一起生长时，淋球菌的死亡比单独生长在Transgrow上的淋病奈瑟氏球更容易死亡。通过在琼脂平板上使用交叉划线技术，已证明白色念珠菌可产生抑制淋病奈瑟氏球菌的可溶性物质，尽管未检测到其他微生物。初步结果表明该抑制因子可通过使用叔丁醇提取。由于生长的Transgrow样本中约有三分之一含有酵母菌，而白色念珠菌是迄今为止最常见的酵母菌，因此该因素在诊断女性淋病方面具有重要意义。

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