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首页> 外文期刊>Applied Microbiology >Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms
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Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms

机译：蓝光对浮游生长和作为成熟生物膜的医院伤口病原菌的抗菌活性。

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The blue wavelengths within the visible light spectrum are intrinisically antimicrobial and can photodynamically inactivate the cells of a wide spectrum of bacteria (Gram positive and negative) and fungi. Furthermore, blue light is equally effective against both drug-sensitive and -resistant members of target species and is less detrimental to mammalian cells than is UV radiation. Blue light is currently used for treating acnes vulgaris and Helicobacter pylori infections; the utility for decontamination and treatment of wound infections is in its infancy. Furthermore, limited studies have been performed on bacterial biofilms, the key growth mode of bacteria involved in clinical infections. Here we report the findings of a multicenter in vitro study performed to assess the antimicrobial activity of 400-nm blue light against bacteria in both planktonic and biofilm growth modes. Blue light was tested against a panel of 34 bacterial isolates (clinical and type strains) comprising Acinetobacter baumannii , Enterobacter cloacae , Stenotrophomonas maltophilia , Pseudomonas aeruginosa , Escherichia coli , Staphylococcus aureus , Enterococcus faecium , Klebsiella pneumoniae , and Elizabethkingia meningoseptica . All planktonic-phase bacteria were susceptible to blue light treatment, with the majority (71%) demonstrating a ≥5-log_(10) decrease in viability after 15 to 30 min of exposure (54 J/cm~(2) to 108 J/cm~(2)). Bacterial biofilms were also highly susceptible to blue light, with significant reduction in seeding observed for all isolates at all levels of exposure. These results warrant further investigation of blue light as a novel decontamination strategy for the nosocomial environment, as well as additional wider decontamination applications.IMPORTANCE Blue light shows great promise as a novel decontamination strategy for the nosocomial environment, as well as additional wider decontamination applications (e.g., wound closure during surgery). This warrants further investigation.
机译：可见光谱内的蓝色波长具有固有的抗菌作用，可以使多种细菌（革兰氏阳性和阴性）和真菌的细胞光动力学失活。此外，蓝光对目标物种的药物敏感性和抗性成员均同样有效，并且与紫外线辐射相比，对哺乳动物细胞的损害较小。蓝光目前用于治疗寻常痤疮和幽门螺杆菌感染。用于消毒和治疗伤口感染的工具尚处于起步阶段。此外，对细菌生物膜（涉及临床感染的细菌的关键生长模式）进行的研究有限。在这里，我们报告了一项多中心体外研究的结果，该研究旨在评估浮游生物和生物膜生长模式下400 nm蓝光对细菌的抗菌活性。对一组包含34个细菌分离株（临床和类型菌株）的蓝光进行了测试，其中包括鲍曼不动杆菌，阴沟肠杆菌，嗜麦芽窄食单胞菌，铜绿假单胞菌，大肠杆菌，金黄色葡萄球菌，粪肠球菌，肺炎克雷伯氏菌和。所有浮游期细菌都容易受到蓝光处理，大多数（71％）表明暴露15至30分钟（54 J / cm〜（2）至108 J）后活力降低≥5-log_（10） / cm〜（2））。细菌生物膜也很容易受到蓝光的影响，在所有暴露水平下，所有分离株的播种量均显着减少。这些结果值得进一步研究蓝光，将其作为一种适用于医院环境的新型去污策略，并应将其应用于更广泛的去污应用中。例如手术中的伤口闭合）。这值得进一步调查。

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