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首页> 外文期刊>Infection and immunity >Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells.
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Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells.

机译：对人类单纯性疱疹的细胞介导免疫：通过从感染细胞释放51-Cr来测量淋巴细胞的细胞毒性。

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摘要

We assessed cell-mediated immunity to herpes simplex virus type 1 antigen in patients suffering from recurrent cold sores and in a series of healthy controls. Paradoxically, all those subject to recurrent herpetic infections had, without exception, evidence of cell-mediated immunity to herpes antigens. This was demonstrated by lymphocyte transformation and specific 51Cr release from infected human amnion cells after incubation with peripheal blood mononuclear cells. Where performed, skin tests with herpes antigen were also positive. In addition, serum from these patients specifically sensitized herpesvirus-infected cells to killing by nonimmune, control mononuclear cells. These tests were negative in the control patients except in a few cases, and it is suggested that these latter may be the asymptomatic herpesvirus carriers previously recognized or that they may have experienced a genital infection.
机译：我们评估了复发性唇疱疹患者和一系列健康对照者对1型单纯疱疹病毒抗原的细胞介导免疫性。矛盾的是，所有遭受复发性疱疹感染的人无一例外都具有细胞介导的针对疱疹抗原的免疫力的证据。与外周血单个核细胞孵育后，淋巴细胞转化和感染的人羊膜细胞中特定的51Cr释放证明了这一点。进行疱疹抗原的皮肤测试也呈阳性。另外，来自这些患者的血清使过敏性疱疹病毒感染的细胞特异性地被非免疫性对照单核细胞杀死。除少数病例外，这些检查在对照组患者中均呈阴性，建议后者可能是先前公认的无症状疱疹病毒携带者，或可能已发生生殖器感染。

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