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首页> 外文期刊>Infection and immunity >Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds.
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Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds.

机译：淋病奈瑟氏球菌，脑膜炎奈瑟氏球菌和共生奈瑟氏球菌从转铁蛋白和铁化合物中获得铁的能力。

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The ability of Neisseria species to use iron compounds and to compete with iron-binding proteins was examined with deferrated defined medium and the iron chelator deferoxamine. All Neisseria species were able to assimilate a variety of ferric and ferrous iron salts. They were not able to efficiently solubilize an inorganic iron salt such as ferric nitrate, but were able to use iron chelated by citrate, oxalacetate, pyrophosphate, or nitrilotriacetate. Each of the 95 Neisseria isolates examined was able to use hemin as a sole source of iron, and most, but not all, of the isolates were able to obtain iron from hemoglobin. Heated human serum stimulated growth of all gonococci, meningococci, and some commensal Neisseria species in iron-deficient medium. All gonococci and meningococci were able to scavenge iron from 25% saturated transferrin, whereas most commensal organisms were inhibited by this iron-binding protein. The ability to compete with transferrin was specific, since partially saturated conalbumin was bacteriostatic for all Neisseria species. Although the pathogenic Neisseria species were able to compete more efficiently with transferrin for iron than were the nonpathogenic Neisseria species, no correlation was observed between the virulence of different strains or colony types of gonococci and the ability to scavenge iron in vitro from transferrin or other chelators.
机译：用延缓的限定培养基和铁螯合剂去铁胺检查了奈瑟氏球菌使用铁化合物和与铁结合蛋白竞争的能力。所有奈瑟氏球菌都能够吸收各种铁盐和亚铁盐。他们不能有效地溶解诸如硝酸铁之类的无机铁盐，但是能够使用被柠檬酸盐，草酰乙酸盐，焦磷酸盐或次氮基三乙酸盐螯合的铁。所检查的95种奈瑟氏菌分离物中的每一种都能够使用血红素作为唯一的铁源，并且大多数（但不是全部）分离物都能够从血红蛋白中获得铁。加热的人血清刺激了缺铁培养基中所有淋球菌，脑膜炎球菌和某些共生奈瑟球菌的生长。所有的淋球菌和脑膜炎球菌都能够从25％的饱和转铁蛋白中清除铁，而大多数共生生物都受到这种铁结合蛋白的抑制。与转铁蛋白竞争的能力是特定的，因为部分饱和的伴生蛋白对所有奈瑟氏菌属均具有抑菌作用。尽管致病性奈瑟氏球菌与转铁蛋白的竞争性比非致病性奈瑟氏球菌更有效，但不同菌株或菌落类型的淋球菌的毒性与体外从转铁蛋白或其他螯合剂清除铁的能力之间没有相关性。 。

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