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首页> 外文期刊>Infection and immunity >Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from lactoferrin.
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Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from lactoferrin.

机译：淋病奈瑟氏球菌，脑膜炎奈瑟氏球菌和共生奈瑟氏球菌从乳铁蛋白获得铁的能力。

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摘要

The ability of 107 Neisseria isolates to compete for iron with human lactoferrin (LF) was examined. Each of 15 meningococci, 53% of 59 selected gonococci, and 24% of 33 commensal Neisseria could use LF-bound iron for growth. Isolates which could not obtain iron from LF were growth inhibited when sufficient LF was added to defined agar medium to bind available free iron. No difference was observed in the ability of colony type 1 and colony type 4 gonococci of the same strain to compete with LF for iron. LF was growth inhibitory for 50% of 22 disseminated disease isolates (DGI strains) and 51% of 35 local urogenital disease isolates (UGI strains). Only 14% of gonococcal isolates requiring arginine, hypoxanthine, and uracil for growth were able to compete with LF for iron, whereas 87% of all other gonococcal isolates could do so (P less than 0.005). Ability to obtain iron from LF does not appear to be required for survival of Neisseria on mucosal surfaces, nor essential for invasion of the bloodstream by gonococci. However, ability to utilize LF as a source of iron may contribute to differences in pathogenicity among certain gonococcal isolates.
机译：检查了107株奈瑟氏菌与人乳铁蛋白（LF）竞争铁的能力。 15个脑膜炎球菌，59个选定的淋球菌中的53％和33个共生奈瑟氏球菌中的24％都可以使用LF结合的铁来生长。当将足够的LF加入确定的琼脂培养基中以结合可用的游离铁时，无法从LF中获得铁的分离株的生长受到抑制。在同一菌株的1型和4型菌落菌中，球菌与LF竞争铁的能力没有差异。 LF对22种已传播疾病分离株（DGI株）中的50％和35种局部泌尿生殖系统疾病分离株（UGI株）中的51％具有生长抑制作用。需要精氨酸，次黄嘌呤和尿嘧啶生长的淋球菌分离株中，只有14％能够与LF竞争铁，而其他所有淋球菌分离株中，有87％可以做到这一点（P小于0.005）。从LF中获得铁的能力似乎对于奈瑟氏菌在粘膜表面的存活不是必需的，也不是淋球菌入侵血流所必需的。但是，利用LF作为铁源的能力可能会导致某些淋球菌分离株之间的致病性差异。

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