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首页> 外文期刊>Infection and immunity >Immunoglobulin Concentrations and Antigen-Specific Antibody Levels in Cervicovaginal Lavages of Rhesus Macaques Are Influenced by the Stage of the Menstrual Cycle
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Immunoglobulin Concentrations and Antigen-Specific Antibody Levels in Cervicovaginal Lavages of Rhesus Macaques Are Influenced by the Stage of the Menstrual Cycle

机译：恒河猴的宫颈阴道灌洗液中的免疫球蛋白浓度和抗原特异性抗体水平受月经周期阶段的影响

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The levels of antigen-specific antibodies (Abs) and immunoglobulins in the cervical mucus of women vary with the menstrual cycle; the highest levels occur during menses, and the lowest occur during the periovulatory period. The rhesus macaque is a widely used animal model of female genital tract immunity. We sought to determine whether rhesus macaques have a cyclical pattern of changing cervicovaginal Ab and immunoglobulin levels that is similar to that of the human female. This study examined the relationship of the stages of the menstrual cycle to genital mucosal and systemic immunoglobulin concentrations and Ab levels in rhesus macaques. In all seven rhesus macaques studied, the immunoglobulins G and A and some antibodies in cervicovaginal lavages varied with the stages of the menstrual cycle, and in many cases this variation reached the level of statistical significance. In a pattern similar to that of women, the highest levels of Abs and immunoglobulins occurred during menses, and the lowest levels occurred around the time of ovulation. However, the Ab and immunoglobulin levels in serum and rectal lavages did not change with the menstrual cycle stage. The results of this study are consistent with the hypothesis that the ovarian hormones that drive the menstrual cycle influence genital tract immunity in female primates.
机译：妇女的宫颈粘液中的抗原特异性抗体（Abs）和免疫球蛋白的水平随月经周期而变化。最高水平发生在月经期间，最低水平发生在月经期。恒河猴是女性生殖道免疫的广泛使用的动物模型。我们试图确定猕猴是否具有与人类女性相似的改变宫颈阴道Ab和免疫球蛋白水平的周期性模式。这项研究检查了恒河猴的月经周期阶段与生殖器粘膜和全身免疫球蛋白浓度以及Ab水平的关系。在所研究的所有七个恒河猴中，宫颈阴道灌洗液中的免疫球蛋白G和A以及一些抗体随月经周期的阶段而变化，并且在许多情况下，这种变化达到了统计上的显着水平。与女性相似，月经期间Abs和免疫球蛋白水平最高，排卵前后最低水平。然而，血清和直肠灌洗液中的Ab和免疫球蛋白水平并未随月经周期而改变。这项研究的结果与以下假设相符：驱动月经周期的卵巢激素会影响雌性灵长类动物的生殖道免疫力。

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