The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy.

A F Barbet; D R Allred

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The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy.

机译：Anaplasma marginale的msp1 beta多基因家族：表达拷贝的核苷酸序列分析。

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A gene for the beta subunit of the immunoprotective surface antigen MSP-1 of Anaplasma marginale was previously cloned and expressed in Escherichia coli. A nucleic acid probe based on this gene detects A. marginale infection in carrier cattle and in the tick vector. We report here the sequence and structural features of the cloned msp1 beta gene and expressed polypeptide. The gene codes for a polypeptide of 756 amino acids that contains domains of tandemly repeated sequence and glutamine-rich regions at the N and C termini. The cloned copy is a member of a multigene family with multiple restriction fragment length polymorphisms in isolates of this rickettsia from different geographical regions. The availability of the sequence will allow use of the polymerase chain reaction in diagnostic assays and the preparation and testing of different vaccine constructs in cattle.

机译：先前已克隆了无缘无花果的免疫保护性表面抗原MSP-1的β亚基的基因，并在大肠杆菌中表达。基于该基因的核酸探针可检测出携带牛和壁虱载体中的边缘margin曲霉感染。我们在这里报告克隆的msp1 beta基因和表达的多肽的序列和结构特征。该基因编码一个756个氨基酸的多肽，该多肽在N和C末端包含串联重复序列的结构域和富含谷氨酰胺的区域。克隆的副本是该立克次氏体分离物中来自不同地理区域的具有多个限制性片段长度多态性的多基因家族的成员。该序列的可用性将允许在诊断测定中使用聚合酶链反应以及在牛中制备和测试不同的疫苗构建体。

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《Infection and immunity》 |1991年第3期|共6页
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A F Barbet; D R Allred;
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中图分类医学免疫学;
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2. Differential Expression and Sequence Conservation of the Anaplasma marginale msp2 Gene Superfamily Outer Membrane Proteins [J] . Susan M. Noh, Kelly A. Brayton, Donald P. Knowles, Infection and immunity . 2006,第6期

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6. The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy. [O] . A F Barbet, D R Allred 1991

机译：Anaplasma marginale的msp1 beta多基因家族：表达拷贝的核苷酸序列分析。
7. Differential Expression and Sequence Conservation of the Anaplasma marginale msp2 Gene Superfamily Outer Membrane Proteins [O] . Noh, Susan M., Brayton, Kelly A., Knowles, Donald P., 2006

机译：Anaplasma marginale msp2基因超家族外膜蛋白的差异表达与序列保守

The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy.

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