Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates.

I E Flesch; S H Kaufmann

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Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates.

机译：γ干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长的机制：活性氮中间体的作用。

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Murine bone marrow-derived macrophages are able to inhibit the growth of Mycobacterium bovis after stimulation with recombinant gamma interferon. This antimycobacterial activity was inhibited by NG-monomethyl-L-arginine, a specific inhibitor of nitrite and nitrate synthesis from L-arginine. Furthermore, there was a complete lack of mycobacterial growth inhibition in a medium deficient in L-arginine. Nitrite is generated by gamma interferon-activated bone marrow-derived macrophages after infection with M. bovis, and a correlation between mycobacterial growth inhibition and nitrite production was observed. These results indicate that reactive nitrogen intermediates derived from L-arginine are crucially involved in macrophage antimycobacterial activity.

机译：鼠骨髓来源的巨噬细胞在重组γ干扰素刺激后能够抑制牛分枝杆菌的生长。这种抗分枝杆菌活性被NG-单甲基-L-精氨酸抑制，NG-单甲基-L-精氨酸是亚硝酸盐和L-精氨酸合成硝酸盐的特异性抑制剂。此外，在缺乏L-精氨酸的培养基中完全缺乏分枝杆菌生长抑制作用。牛分枝杆菌感染后，γ干扰素激活的骨髓来源的巨噬细胞产生亚硝酸盐，并且观察到分枝杆菌生长抑制与亚硝酸盐产生之间的相关性。这些结果表明，衍生自L-精氨酸的反应性氮中间体至关重要地参与了巨噬细胞的抗分枝杆菌活性。

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《Infection and immunity》 |1991年第9期|共6页
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I E Flesch; S H Kaufmann;
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1. Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages. [J] . I E Flesch, S H Kaufmann Infection and immunity . 1988,第6期

机译：试图表征γ-干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长的机制。
2. Granulocyte-macrophage colony-stimulating factor is not involved in production of reactive nitrogen intermediates by or toxoplasmastatic activity of gamma interferon-activated murine macrophages. [J] . A Buisman, J T van Dissel, J A Langermans, Infection and immunity . 1994,第3期

机译：粒细胞-巨噬细胞集落刺激因子不参与γ干扰素激活的鼠巨噬细胞的活性或杀虫活性。
3. In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates. [J] . C K Edwards, S M Ghiasuddin, L M Yunger, Infection and immunity . 1992,第6期

机译：体内重组生长激素或γ干扰素活性巨噬细胞的给药：对鼠伤寒沙门氏菌感染的增强抵抗力与活性氧中间体的产生有关。
4. Mechanisms Involved by Reactive Elements upon High Temperature Chromia Scale Growth [C] . S. Chevalier, G. Bonnet, G. Borchardt, 5th International Symposium on High Temperature Corrosion and Protection of Materials, 5th, May - mai 22-26, 2000, Les Embiez, France . 2000

机译：反应性元素参与高温铬鳞片生长的机理
5. Distinct, gene-specific mechanisms mediate inhibition of macrophage responses to interferon gamma by Mycobacterium tuberculosis. [D] . Benson, Sarah A. 2009

机译：不同的，基因特异性的机制介导结核分枝杆菌抑制巨噬细胞对干扰素γ的应答。
6. Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. [O] . I E Flesch, S H Kaufmann 1991

机译：γ干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长的机制：活性氮中间体的作用。
7. Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates [O] . I E Flesch, S H Kaufmann 1991

机译：γ干扰素活化骨髓巨噬细胞涉及分枝杆菌生长抑制的机制：反应性氮中间体的作用
8. Bone Marrow and Splenic Granulocyte-Macrophage Colony-Stimulating Factor andTransforming Growth Factor-beta mRNA Levels In Irradiated Mice [R] . Chang, C. M., Limanni, A., Baker, W. H., 1995

机译：骨髓和脾粒细胞 - 巨噬细胞集落刺激因子和转化生长因子-βmRNa水平在辐射小鼠中的应用

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates.

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