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首页> 外文期刊>Infection and immunity >Trypanosoma cruzi but not Trypanosoma brucei fails to induce a chemiluminescent signal in a macrophage hybridoma cell line.
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Trypanosoma cruzi but not Trypanosoma brucei fails to induce a chemiluminescent signal in a macrophage hybridoma cell line.

机译：克氏锥虫而不是布鲁氏锥虫不能在巨噬细胞杂交瘤细胞系中诱导化学发光信号。

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摘要

Macrophage-Trypanosoma cruzi interactions were studied by using a newly generated macrophage hybridoma cell line (2C11-12) that was selected for its capacity to produce high levels of reactive oxygen intermediates. This cell line was found to be a suitable host cell for T. cruzi, and intracellular parasitic development could be inhibited by activation with gamma interferon. When exposed to opsonized Trypanosoma brucei, Micrococcus lysodeikticus, or Legionella pneumophila, the activated macrophage cell line produces a high chemiluminescent signal, indicating the release of reactive oxygen intermediates. Alternatively, when opsonized T. cruzi was added to these activated macrophages, this parasite failed to stimulate a chemiluminescent response, suggesting an impairment in the triggering of the respiratory burst.
机译：通过使用新产生的巨噬细胞杂交瘤细胞系（2C11-12）研究了巨噬细胞与克鲁斯锥虫的相互作用，该细胞系能够产生高水平的活性氧中间体。发现该细胞系是克鲁维酵母的合适宿主细胞，并且γ-干扰素的激活可以抑制细胞内的寄生虫发育。当暴露于调理的布鲁氏锥虫，溶血微球菌或嗜肺军团杆菌时，活化的巨噬细胞系会产生高化学发光信号，表明释放了活性氧中间体。另外，当将调理克氏克氏菌添加到这些活化的巨噬细胞中时，该寄生虫不能刺激化学发光反应，表明呼吸爆发的触发受到损害。

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