Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae: Implications for Virulence Studies of Encapsulated Strains

Jeffrey N. Weiser; Miki Kapoor

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Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae: Implications for Virulence Studies of Encapsulated Strains

机译：囊内多糖量的菌株内变异对肺炎链球菌遗传转化的影响：对包囊菌株的致病性研究的意义。

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The degrees of competence of opaque and transparent colony variants of Streptococcus pneumoniae were compared. The transparent variants were transformed at 9- to 670-fold-higher rates than the opaque variants, independent of the DNA incorporated, due to decreased expression of capsular polysaccharide. Genetic transformation, therefore, tends to select for a less-encapsulated subpopulation.

机译：比较了肺炎链球菌的不透明和透明菌落变异体的能力程度。由于荚膜多糖的表达降低，透明变体以比不透明变体高9至670倍的速率转化，而与掺入的DNA无关。因此，遗传转化倾向于选择封装较少的亚群。 展开▼

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《Infection and immunity》 |1999年第7期|共3页

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Jeffrey N. Weiser; Miki Kapoor;
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中图分类医学免疫学;

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1. Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae: Implications for Virulence Studies of Encapsulated Strains [J] . Jeffrey N. Weiser, Miki Kapoor Infection and immunity . 1999,第7期

机译：囊内多糖量的菌株内变异对肺炎链球菌遗传转化的影响：对包囊菌株的致病性研究的意义。

2. Determination of native capsular polysaccharide structures of Streptococcus pneumoniae serotypes 39, 42, and 47F and comparison to genetically or serologically related strains [J] . Bent O. Petersen, Sebastian Meier, Berit Smestad Paulsen, Carbohydrate research . 2014,第Null期

机译：肺炎链球菌血清型39、42和47F的天然荚膜多糖结构的确定以及与遗传或血清学相关菌株的比较

3. Relative Roles of Genetic Background and Variation in PspA in the Ability of Antibodies to PspA To Protect against Capsular Type 3 and 4 Strains of Streptococcus pneumoniae [J] . Hazeline Roche, Bing Ren, Larry S. McDaniel, Infection and immunity . 2003,第8期

机译：PspA的遗传背景和变异在抗PspA抗体抵抗肺炎链球菌荚膜3型和4型菌株的能力中的相对作用。

4. COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS. [C] . Michelle M. Kuttel, Neil Ravenscroft International Carbohydrate Symposium . 2018

机译：链球菌血清型III和链球菌血管型血管型血管型血管型血管型血管型14的比较14：免疫学的影响。

5. Characterization of Streptococcus pneumoniae Type 3 capsular polysaccharide biosynthesis. [D] . Cartee, Robert Thompson. 2000

机译：肺炎链球菌3型荚膜多糖生物合成的表征。

6. Note: Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae: Implications for Virulence Studies of Encapsulated Strains [O] . Jeffrey N. Weiser, Miki Kapoor 1999

机译：注意：囊内多糖量的株内变异对肺炎链球菌遗传转化的影响：包囊菌株的毒力研究的意义。

7. Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae : Implications for Virulence Studies of Encapsulated Strains [O] . Jeffrey N. Weiser, Miki Kapoor 1999

机译：囊肿多糖肠道多糖的影响对肺炎链球菌遗传转化的影响：封装菌株毒力研究的影响

8. Dendritic Cell-Derived Exosomes Express a Streptococcus pneumoniae Capsular Polysaccharide Type 14 Cross-Reactive Antigen That Induces Protective Immunoglobulin Responses against Pneumococcal Infection in Mice [R] . Colino, J., Snapper, C. M. 2007

机译：树突状细胞衍生外泌体表达肺炎链球菌荚膜多糖14型交叉反应抗原诱导保护性免疫球蛋白对小鼠肺炎球菌感染的反应

1. 环链棒束孢菌株培养特征、致病性及遗传变异研究 [J] . 韩燕峰 ,张延威 ,梁建东 . 菌物学报 . 2012,第003期

2. 尼罗罗非鱼无乳链球菌荚膜多糖合成基因的表达及其与r荚膜唾液酸含量、菌株致病性的关系 [J] . 师红亚 ,董浚键 ,张德锋 . 水产学报 . 2018,第002期

3. 尼罗罗非鱼无乳链球菌荚膜多糖合成基因的表达及其与荚膜唾液酸含量、菌株致病性的关系 [J] . 师红亚12 ,董浚键1 ,孙成飞1 . 珠江水产科学 . 2017,第004期

4. pUC19-pbp2b重组质粒转化对肺炎链球菌感受态菌株耐药性的影响 [J] . 赵卫东 ,忽胜和 ,杨新原 . 广西医学 . 2016,第011期

5. 红霉素耐药的肺炎链球菌亚株转化敏感受体菌株R6的耐药机制研究 [J] . 车建强 . 中国农村卫生 . 2012,第0z2期

6. 猪链球菌病菌株分离鉴定及致病性研究 [C] . 王红宝 ,李红丽 ,郭雪丽 . 中国畜牧兽医学会兽医病理学分会第二十次学术研讨会暨中国病理生理学会动物病理生理专业委员会第十九次学术研讨会 . 2014

7. 不同龋敏感儿童口腔变异链球菌临床分离株不同基因型菌株有机酸及胞外多糖产生能力的实验研究 [A] . 李静 . 2009

1. Immunogenic composition comprising a mixture of conjugated polysaccharide - Protein which consists of multivalent Streptococcus pneumoniae capsular polysaccharide; method to induce a resImmune to a set of Streptococcus pneumoniae capsular polysaccharide. [P] . 外国专利： CL2012002195A1 . 2012-11-30

机译：包含结合多糖的混合物的免疫原性组合物-由多价肺炎链球菌荚膜多糖组成的蛋白质;诱导对一组肺炎链球菌荚膜多糖的免疫的方法。

2. Streptococcus pneumoniae producing hybrid polyserotype capsular polysaccharide and hybrid polyserotype capsular polysaccharide produced therefrom [P] . 外国专利： KR101712495B1 . 2017-03-07

机译：产生杂交多血清型荚膜多糖的肺炎链球菌和由其产生的杂交多血清型荚膜多糖

3. STREPTOCOCCUS PNEUMONIAE PRODUCING HYBRID POLYSEROTYPE CAPSULAR POLYSACCHARIDE AND HYBRID POLYSEROTYPE CAPSULAR POLYSACCHARIDE PRODUCED THEREFROM [P] . 外国专利： KR20150021624A . 2015-03-03

机译：产链球菌肺炎链球菌混合型多囊型多糖和由此制得的杂交多球菌型囊状多糖

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Effect of Intrastrain Variation in the Amount of Capsular Polysaccharide on Genetic Transformation of Streptococcus pneumoniae: Implications for Virulence Studies of Encapsulated Strains

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