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首页> 外文期刊>Infection and immunity >Local Immune Responses to Chlamydia pneumoniae in the Lungs of BALB/c Mice during Primary Infection and Reinfection
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Local Immune Responses to Chlamydia pneumoniae in the Lungs of BALB/c Mice during Primary Infection and Reinfection

机译：初次感染和再感染过程中BALB / c小鼠肺部对肺炎衣原体的局部免疫反应

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Cell-mediated immune (CMI) responses play a major role in protection as well as pathogenesis of many intracellular bacterial infections. In this study, we evaluated the infection kinetics and assessed histologically the lymphoid reactions and local, in vitro-restimulated CMI responses in lungs of BALB/c mice, during both primary infection and reinfection with Chlamydia pneumoniae. The primary challenge resulted in a self-restricted infection with elimination of culturable bacteria by day 27 after challenge. A mild lymphoid reaction characterized the pathology in the lungs. In vitro CMI responses consisted of a weak proliferative response and no secretion of gamma interferon (IFN-γ). The number of lung-derived mononuclear cells increased substantially during the primary infection; the largest relative increase was observed in B cells (B220+). After reinfection, the number of lung-derived mononuclear cells increased further, and the response consisted mainly of T cells. The reinfection was characterized in vivo by significant protection from infection (fewer cultivable bacteria in the lungs for a shorter period of time) but increased local lymphoid reaction at the infection site. In vitro, as opposed to the response in naive mice, acquired immunity was characterized by a strongly Th1-biased (IFN-γ) CMI response. These results suggest that repeated infections with C. pneumoniae may induce Th1-type responses with similar associated tissue reactions, as shown in C. trachomatis infection models.
机译：细胞介导的免疫（CMI）反应在许多细胞内细菌感染的保护以及发病机理中起着重要作用。在这项研究中，我们评估了肺炎衣原体的初次感染和再感染过程中BALB / c小鼠肺部的感染动力学，并从组织学角度评估了淋巴样反应和局部，体外再刺激的CMI反应。最初的攻击导致自我限制的感染，并在攻击后第27天消除了可培养细菌。轻度淋巴样反应是肺部病理的特征。体外CMI反应包括较弱的增殖反应，且无γ干扰素（IFN-γ）分泌。在初次感染过程中，肺源性单核细胞数量大量增加;在B细胞中观察到最大的相对增加（B220 + ）。再感染后，肺源性单核细胞数量进一步增加，反应主要由T细胞组成。体内的再感染的特征是对感染具有显着的保护作用（在较短的时间内，肺中可培养的细菌较少），但感染部位的局部淋巴样反应却增加了。在体外，与幼稚小鼠的反应相反，获得性免疫的特征是强烈的Th1偏向（IFN-γ）CMI反应。这些结果表明重复感染 C。如 C所示，肺炎可能诱导Th1型反应，并伴有类似的组织反应。沙眼菌感染模型。

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