• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Host resistance to an intragastric infection with Listeria monocytogenes in mice depends on cellular immunity and intestinal bacterial flora.
【24h】

Host resistance to an intragastric infection with Listeria monocytogenes in mice depends on cellular immunity and intestinal bacterial flora.

机译：宿主对小鼠单核细胞增生性李斯特菌胃内感染的抵抗力取决于细胞免疫力和肠道细菌菌群。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Suckling and adult mice were infected intragastrically with different doses of viable Listeria monocytogenes. The 50% lethal dose for the intragastric infection was 10(3.7) CFU for suckling mice, while adult mice were highly resistant and the 50% lethal dose was more than 10(9.3) CFU. When adult mice were infected intragastrically with 5 x 10(8) CFU of L. monocytogenes, no mice died. However, 35% of adult mice died when they were treated with cyclosporin A 1 day before infection. Although mice did not die when treated with an L. monocytogenes-resistant broad-spectrum cephalosporin, sodium cefbuperazone, before and during infection, the number of L. monocytogenes bacteria increased in the feces. The sodium cefbuperazone treatment of mice resulted in superinfection, i.e., a marked decrease of Escherichia coli and an increase of Enterococcus spp. in the intestines. Furthermore, host resistance against the intragastric infection markedly decreased when the mice were treated with both drugs. The growth of L. monocytogenes was augmented in the spleens, mesenteric lymph nodes, Peyer's patches, and feces, and the mortality of the mice was 65%. These results suggest that both cellular immunity and the intestinal bacterial flora are required for host resistance against oral L. monocytogenes infection.
机译：乳鼠和成年小鼠在胃内感染了不同剂量的单核细胞增生李斯特菌。对于哺乳小鼠，胃内感染的50％致死剂量为10（3.7）CFU，成年小鼠具有高度耐药性，且50％致死剂量大于10（9.3）CFU。当成年小鼠在胃内感染5 x 10（8）CFU单核细胞增生李斯特菌时，没有小鼠死亡。但是，在感染前1天用环孢菌素A治疗的成年小鼠中有35％死亡。尽管在感染前和感染过程中用抗单核细胞增生李斯特氏菌广谱头孢菌素钠头孢哌酮处理的小鼠并未死亡，但粪便中单核细胞增生李斯特菌的数量增加了。小鼠头孢哌酮钠的治疗导致超级感染，即大肠杆菌的显着减少和肠球菌的增加。在肠子里。此外，当用两种药物治疗小鼠时，宿主对胃内感染的抵抗力显着降低。单核细胞增生李斯特氏菌的生长在脾脏，肠系膜淋巴结，派伊尔氏淋巴结和粪便中增加，小鼠的死亡率为65％。这些结果表明，宿主抵抗口服单核细胞增生李斯特菌感染需要细胞免疫力和肠道细菌菌群。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号