Can Outer Membrane Vesicle of Group B Meningococci be Applied as an Adjuvant in Immunization of the Rabbit Against Serogroup A Neisseria Meningitidis?

M.Nejati; S.D.Siadat; B.Tabaraie; D.Norouzian; S.H. NajarPeerayeh; M.Alimagham; M.Zangeneh; A. SharifatSalmani

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Can Outer Membrane Vesicle of Group B Meningococci be Applied as an Adjuvant in Immunization of the Rabbit Against Serogroup A Neisseria Meningitidis?

机译：B组脑膜炎球菌外膜囊泡可作为佐剂免疫兔抗A群脑膜炎奈瑟球菌吗？

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Background: Since the use of new adjuvants in designing new vaccines against most of infectious diseases should be improved, many candidates are recommended for modulating an immune response to an antigen. Neisseria meningitidis serogroup B outer membrane vesicle (OMV) has been used previously by Siadat et al (2007), as a carrier for polysaccharide immunogens. In this study OMV used as an adjuvant for group A meningococcal capsular polysaccharide (GAMP) and was tested in Newzeland white rabbit for bactericidal antibody activity induction.Keywords: OMV, Adjuvant, Neisseria meningitidis serogroup A & B, Bactericidal activity

机译：背景：由于应改进在设计针对大多数传染性疾病的新疫苗中使用新佐剂的方法，因此建议许多候选药物调节对抗原的免疫反应。 Siadat等人（2007年）先前已将脑膜炎奈瑟氏球菌血清群B外膜囊泡（OMV）用作多糖免疫原的载体。在这项研究中，OMV用作A组脑膜炎球菌荚膜多糖（GAMP）的佐剂，并在新西兰白兔中测试了其杀菌抗体的诱导活性。关键词：OMV，佐剂，脑膜炎奈瑟氏球菌血清A和B群，杀菌活性

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《International journal of infectious diseases :》 |2008年第1期|共页
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M.Nejati; S.D.Siadat; B.Tabaraie; D.Norouzian; S.H. NajarPeerayeh; M.Alimagham; M.Zangeneh; A. SharifatSalmani;
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1. Outer membrane vesicle of Neisseria meningitidis serogroup B as an adjuvant in immunization of rabbit against Neisseria meningitidis serogroup A [J] . Seyed Davar Siadat, Saied Reza Naddaf, Mehrangiz Zangeneh, African Journal of Microbiology Research . 2011,第19期

机译：Neisseria Meningitidis血清群B的外膜囊泡作为兔子免疫兔子免疫接种脑膜脑霉菌血清群A辅助剂
2. Comparison Among Opsonic Activity and Serum Bactericidal Activity Against Meningococci in Rabbit Sera from Vaccines After Immunization with Outer Membrane Vesicle of Neisseria meningitidis Serogroup B [J] . Q. Behzadiyannejad, S.D. Siadat, M. Kheirandish, Research journal of microbiology. . 2008,第3期

机译：脑膜炎双球菌血清群B的外膜囊泡免疫后，兔血清中脑膜炎球菌的调理活性和血清杀菌活性的比较
3. Evaluation of Serum Bactericidal Activity Specific for Neisseria meningitidis Serogroup A and B: Effect of Immunization with Neisseria meningitidis Serogroup A Polysaccharide and Serogroup B Outer Membrane Vesicle Conjugate as a Bivalent Meningococcus Vac [J] . S.D. Siadat, Q. Behzadiyannejad, B. Tabaraie, Research journal of microbiology. . 2007,第5期

机译：评价脑膜炎奈瑟氏球菌血清群A和B特异的血清杀菌活性：脑膜炎奈瑟氏菌血清群A多糖和血清群B外膜囊泡结合为二价脑膜炎球菌疫苗的免疫效果
4. Assessment of intact Phospholipids in Outer Membrane Vesicles of Neisseria meningitidis Serogroup B Bacteria with nanoscale LC-MS [C] . Hugo D. Meiring, Martin R.J. Hamzink, Bert Zomer, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：用纳米级LC-MS评估Neisseria Meningitidis Serogroup B细菌外膜囊泡的完整磷脂
5. Biochemical Assays of the Neisseria meningitidis Serogroup W Capsule Polymerase [D] . Sharyan, Abeer. 2018

机译：Neisseria Meningitidis血清群的生化测定胶囊聚合酶
6. Immunization with Recombinant Opc Outer Membrane Protein from Neisseria meningitidis: Influence of Sequence Variation and Levels of Expression on the Bactericidal Immune Response against Meningococci [O] . Keith A. Jolley, Lynn Appleby, J. Claire Wright, 2001

机译：脑膜炎奈瑟氏球菌重组Opc外膜蛋白的免疫：序列变异和表达水平对针对脑膜炎球菌的杀菌免疫反应的影响。
7. Can Outer Membrane Vesicle of Group B Meningococci be Applied as an Adjuvant in Immunization of the Rabbit Against Serogroup A Neisseria Meningitidis? [O] . Nejati M., Siadat S.D., Tabaraie B., 2008

机译：B组脑膜炎球菌外膜囊泡可作为佐剂免疫兔抗A群脑膜炎奈瑟球菌吗？
8. Development of a Vaccine for Neisseria Meningitidis Group B Based on Native Outer Membrane Vesicles; Conference paper [R] . Zollinger, W. D., Fisseha, M., Brandt, B. L., 2006

机译：基于天然外膜膜的脑膜炎奈瑟菌B组疫苗的研制;会议论文

Can Outer Membrane Vesicle of Group B Meningococci be Applied as an Adjuvant in Immunization of the Rabbit Against Serogroup A Neisseria Meningitidis?

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