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首页> 外文期刊>International Journal of Molecular Sciences >A Comparative Analysis of the Photo-Protective Effects of Soy Isoflavones in Their Aglycone and Glucoside Forms
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A Comparative Analysis of the Photo-Protective Effects of Soy Isoflavones in Their Aglycone and Glucoside Forms

机译：大豆异黄酮糖苷和糖苷形式的光保护作用的比较分析

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摘要

Isoflavones exist in nature predominantly as glucosides such as daidzin or genistin and are rarely found in their corresponding aglycone forms daidzein and genistein. The metabolism and absorption of isoflavones ingested with food is well documented, but little is known about their use as topical photo-protective agents. The aim of this study was to investigate in a comparative analysis the photo-protective effects of isoflavones in both their aglycone and glucoside forms. In human skin fibroblasts irradiated with 60 mJ/cm2 ultraviolet B (UVB), we measured the expression levels of COX-2 and Gadd45, which are involved in inflammation and DNA repair, respectively. We also determined the cellular response to UVB-induced DNA damage using the comet assay. Our findings suggest that both the isoflavone glucosides at a specific concentration and combination with an aglycone mixture exerted an anti-inflammatory and photo-protective effect that prevented 41% and 71% of UVB-induced DNA damage, respectively. The advantages of using either isoflavone glucosides or an aglycone mixture in applications in the field of dermatology will depend on their properties and their different potential uses.
机译：异黄酮在自然界中主要以苷类存在，如大豆苷或染料木苷，而在大豆苷元和染料木黄酮的相应糖苷配基中则很少见。食物中摄取的异黄酮的代谢和吸收已有详细记录，但关于它们作为局部光保护剂的用途知之甚少。这项研究的目的是在比较分析中研究异黄酮苷元和糖苷形式的光保护作用。在60 mJ / cm 2 紫外线B（UVB）照射的人皮肤成纤维细胞中，我们测量了COX-2和Gadd45的表达水平，它们分别参与炎症和DNA修复。我们还使用彗星试验确定了细胞对UVB诱导的DNA损伤的反应。我们的发现表明，特定浓度的异黄酮葡萄糖苷以及与糖苷配基混合物的组合均发挥了抗炎和光保护作用，分别防止了41％和71％的UVB诱导的DNA损伤。在皮肤病学领域中使用异黄酮葡萄糖苷或糖苷配基混合物的优势将取决于它们的性质和不同的潜在用途。

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