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首页> 外文期刊>International journal of infectious diseases : >Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam
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Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam

机译：越南芽庄儿童呼吸道病毒季节性流行导致儿童因急性呼吸道感染而住院

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Background Acute respiratory infections (ARIs) are the most common causes of death in children under 5 years of age. While the etiology of most pneumonia and ARI episodes is undiagnosed, a broad range of ARI-causing viruses circulate widely in South East Asia. However, the patterns and drivers of the seasonal transmission dynamics are largely unknown. Here we identify the seasonal patterns of multiple circulating viruses associated with hospitalizations for ARIs in Nha Trang, Vietnam. Methods Hospital based enhanced surveillance of childhood ARI is ongoing at Khanh Hoa General Hospital in Nha Trang. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. Seasonal patterns of childhood ARI hospital admissions of various viruses were assessed, as well as their association with rainfall, temperature, and dew point. Results Respiratory syncytial virus peaks in the late summer months, and influenza A in April to June. We find significant associations between detection of human parainfluenza 3 and human rhinovirus with the month's mean dew point. Using a cross-wavelet transform we find a significant out-of-phase relationship between human parainfluenza 3 and temperature and dew point. Conclusions Our results are important for understanding the temporal risk associated with circulating pathogens in Southern Central Vietnam. Specifically, our results can inform timing of routing seasonal influenza vaccination and for when observed respiratory illness is likely viral, leading to judicious use of antibiotics in the region.
机译：背景技术急性呼吸道感染（ARIs）是5岁以下儿童最常见的死亡原因。尽管大多数肺炎和ARI发作的病因尚未得到诊断，但东南亚引起广泛的引起ARI的病毒广泛流传。但是，季节性传播动态的模式和驱动因素在很大程度上是未知的。在这里，我们确定了与越南芽庄ARI住院相关的多种循环病毒的季节性模式。方法芽庄市庆和总医院正在进行以医院为基础的儿童ARI增强监视。进行RT-PCR以检测入组患者鼻咽样品中的13种呼吸道病毒。评估了儿童ARI入院时各种病毒的季节性分布及其与降雨，温度和露点的关系。结果呼吸道合胞病毒在夏季末期达到峰值，在四月至六月间发生甲型流感。我们发现人类副流感3和人类鼻病毒的检测与月平均露点之间存在显着关联。使用交叉小波变换，我们发现人副流感3与温度和露点之间存在明显的异相关系。结论我们的结果对于了解越南中南部与循环病原体相关的时间风险非常重要。具体而言，我们的结果可以为季节性流感疫苗接种的时间安排以及何时观察到的呼吸道疾病可能是病毒性感染，从而导致该地区明智地使用抗生素提供信息。

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