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Active Cytomegalovirus Infection in Patients with Septic Shock

机译:感染性休克患者活动性巨细胞病毒感染

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Cytomegalovirus (CMV) is a pathogen of emergingimportance for patients with septic shock. In this prospec-tive study, 25 immunocompetent CMV-seropositive patientswith septic shock and an intensive care unit stay of >7 dayswere monitored by using quantitative pp65-antigenemiaassay, shell vial culture, and virus isolation. Within 2 weeks,active CMV infection with low-level pp65-antigenemia(median 3 positive/5×105leukocytes) developed in 8 (32%)patients. Infection was controlled within a few weeks (medi-an 26 days) without use of antiviral therapy. Duration ofintensive care and mechanical ventilation were significant-ly prolonged in patients with active CMV infection. CMVreactivation was associated with concomitant herpes sim-plex virus reactivation (p = 0.004). The associationbetween active CMV infection and increased illness couldopen new therapeutic options for patients with septicshock. Future interventional studies are required
机译:巨细胞病毒(CMV)是败血性休克患者新兴的重要病原体。在这项前瞻性研究中,通过定量pp65-抗原血症测定,壳管小瓶培养和病毒分离监测了25名具有感染性休克且重症监护病房停留时间超过7天的免疫活性CMV血清反应阳性的患者。在2周内,有8位(32%)患者出现了低水平pp65-抗原血症(中位数3阳性/ 5×105白细胞)的主动CMV感染。在不使用抗病毒治疗的情况下,感染在几周内(中等至26天)得到控制。活动性CMV感染患者的重症监护和机械通气时间显着延长。 CMV的重新激活与单纯疱疹病毒复合体的重新激活有关(p = 0.004)。活跃的CMV感染与疾病增加之间的关联可能为败血症性休克患者打开新的治疗选择。需要未来的干预研究

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