...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase bla Gene
【24h】

Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase bla Gene

机译：产生β-内酰胺酶bla基因的肺炎克雷伯菌的全球多样性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Klebsiella pneumoniae isolates that produce carbap-enemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 blaKPC-2-harboring K. pneumoniae isolates from 5 coun-tries. The isolates were multidrug resistant, possessed the blaKPC-2gene, and differed by additional β-lactamase con-tent. They harbored a naturally chromosome-encoded bla gene (blaSHV-1[12.5%], blaSHV-11[68.7%], or blaOKP-A/B[18.8%]) and several acquired and plasmid-encoded genes (blaTEM-1[81.3%], blaCTX-M-2[31.3%], blaCTX-M-12[12.5%], blaCTX-M-15[18.7%], and blaOXA-9[37.5%]). The blaKPC-2gene was always associated with 1 of the Tn4401 isoforms (a, b, or c). Tn4401 was inserted on different-sized plasmids that belonged to different incompatibility groups. Several blaKPC-containing K. pneumoniae clones were found: 9 different pulsotypes with 1 major (sequence type 258) and 7 minor distinct al-lelic profi les. Different clones harboring different plasmids but having identical genetic structure, Tn4401, could be at the origin of the worldwide spread of this emerging resis-tance gene
机译：产生卡巴灌肠剂（KPC）的肺炎克雷伯菌分离株正在全球范围内迅速传播。为了确定其遗传背景，我们调查了来自5个国家的16株blaKPC-2携带肺炎克雷伯菌。分离株具有多药耐药性，具有blaKPC-2基因，并且与其他β-内酰胺酶含量不同。他们拥有一个天然的染色体编码的bla基因（blaSHV-1 [12.5％]，blaSHV-11 [68.7％]或blaOKP-A / B [18.8％]）和几个获得的质粒编码基因（blaTEM-1 [ 81.3％]，blaCTX-M-2 [31.3％]，blaCTX-M-12 [12.5％]，blaCTX-M-15 [18.7％]和blaOXA-9 [37.5％]。 blaKPC-2基因始终与Tn4401亚型之一（a，b或c）相关。将Tn4401插入属于不同不相容性组的不同大小的质粒。发现了几个含有blaKPC的肺炎克雷伯菌克隆：9种不同的脉冲型，其中1种主要（序列类型258）和7种次要的不同唾液酸谱。携带不同质粒但具有相同遗传结构的不同克隆Tn4401可能是该新兴抗性基因在世界范围内传播的起点

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号