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首页> 外文期刊>Emerging Infectious Diseases >Molecular Evidence of Clonal Vibrio parahaemolyticus Pandemic Strains
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Molecular Evidence of Clonal Vibrio parahaemolyticus Pandemic Strains

机译：副溶血性弧菌大流行株的分子证据

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The upsurge in worldwide incidence of Vibrio parahaemolyticus infection in the last 5 years has been attributed to the recent appearance of three serotypes with pandemic potential: O3:K6, O4:K68, and O1:K untypeable (KUT). Thirty-five strains of these serotypes, isolated from different countries over 4 years, were characterized by ribotyping and pulsed-field gel electrophoresis to determine their origin. The ribotypes of the strains of these serotypes were indistinguishable, except for a Japanese tdhnegative O3:K6 strain and a U.S. clinical O3:K6 isolate, which had slightly different profiles. The migration patterns of the NotI-digest of the total DNA of the strains were similar, and only slight variations were observed between the serotypes. By contrast, the O3:K6 and O1:KUT strains isolated before 1995 and strains of other serotypes had markedly different profiles. The O4:K68 and O1:KUT strains most likely originated from the pandemic O3:K6 clone.a
机译：过去五年来，全球副溶血性弧菌感染的上升是由于最近出现了三种具有大流行潜力的血清型：O3：K6，O4：K68和O1：K无法分型（KUT）。通过核糖分型和脉冲场凝胶电泳来确定来自不同国家的4年以上的35种这些血清型菌株的来源。这些血清型的菌株的核糖型没有区别，除了日本特异的O3：K6菌株和美国临床的O3：K6分离株，它们的外形略有不同。菌株总DNA中NotI消化的迁移模式是相似的，并且在血清型之间仅观察到轻微的变化。相比之下，1995年之前分离出的O3：K6和O1：KUT菌株与其他血清型的菌株具有明显不同的特征。 O4：K68和O1：KUT菌株最有可能源自大流行的O3：K6克隆。

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