We evaluated prognostic factors for leptospirosis in 168 consecutive hospitalized patients in Guadeloupe. Fac-tors independently associated with severity included chronic hypertension or chronic alcoholism, late initiation of antibac-terial therapy, abnormal chest auscultation results, icterus, oligoanuria, disorders of consciousness, elevated aspartate aminotransferase levels, hyperamylasemia, and Leptospira interrogans serovar Icterohemorrhagiae
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