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首页> 外文期刊>Molecular and Cellular Biology >Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.
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Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

机译：在AKXD鼠髓样肿瘤的DNA中鉴定出常见的向生型病毒整合位点Evi-1。

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AKXD-23 recombinant inbred mice develop myeloid tumors at a high frequency, unlike other AKXD recombinant inbred strains which develop B-cell lymphomas, T-cell lymphomas, or both. AKXD-23 myeloid tumors are monoclonal, and their DNA contains somatically acquired proviruses, suggesting that they are retrovirally induced. We identified a common site of ecotropic proviral integration that is present in the DNA of all AKXD-23 myeloid tumors that were analyzed and in the DNA of all myeloid tumors that occur in AKXD strains other than AKXD-23. We designated this locus Evi-1 (ecotropic viral integration site 1). Rearrangements in the Evi-1 locus were also detected in the DNA of a number of myeloid tumors and myeloid cell lines isolated from strains other than AKXD. In contrast, few Evi-1 rearrangements were detected in the DNA of T- or B-cell tumors. Evi-1 may thus identify a new proto-oncogene locus that is involved in myeloid disease.
机译：AKXD-23重组近交小鼠以高频率发展骨髓瘤，这与其他AKXD重组近交菌株产生B细胞淋巴瘤和/或T细胞淋巴瘤不同。 AKXD-23髓样肿瘤是单克隆的，其DNA包含体细胞获得的前病毒，表明它们是逆转录病毒诱导的。我们确定了亲生态性原病毒整合的共同位点，该位点存在于所有已分析的AKXD-23髓样肿瘤的DNA中以及存在于除AKXD-23之外的AKXD菌株中的所有髓样肿瘤的DNA中。我们将此基因座指定为Evi-1（促性病毒整合位点1）。在从除AKXD之外的其他菌株中分离的许多髓样肿瘤和髓样细胞系的DNA中也检测到Evi-1基因座的重排。相反，在T细胞或B细胞肿瘤的DNA中几乎没有检测到Evi-1重排。因此，Evi-1可能会鉴定出一种新的原癌基因位点，该位点与髓样疾病有关。

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