Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

T Tamura; A Aoyama; T Inoue; M Miura; H Okano; K Mikoshiba

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Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

机译：从小鼠髓鞘碱性蛋白启动子进行的组织特异性体外转录。

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The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from -253 to -54 directed preferential transcription in brain extracts, whereas the same region repressed transcription activity in liver extracts. Stimulation of transcription was observed when the distal region was located only in a native orientation. The proximal region downstream from -53 alone still directed preferential transcription. It is suggested that cooperative function by the two promoter regions may be required for higher specificity.

机译：小鼠髓磷脂碱性蛋白启动子被转录到脑核提取物中。从-253到-54的远端启动子区域指导脑提取物中的优先转录，而同一区域抑制肝提取物中的转录活性。当远端区域仅位于自然方向时，观察到转录的刺激。仅-53下游的近端区域仍指导优先转录。建议更高的特异性可能需要两个启动子区域的协同功能。

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《Molecular and Cellular Biology》 |1989年第7期|共5页
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T Tamura; A Aoyama; T Inoue; M Miura; H Okano; K Mikoshiba;
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中图分类细胞生物学;
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专利

1. Demonstration of a transcription element in vitro between the capping site and translation initiation site of the mouse myelin basic protein gene [J] . Mikoshiba Katsuhiko, Tamura Taka-aki FEBS Letters . 1991,第1期

机译：在小鼠髓鞘碱性蛋白基因的加帽位点和翻译起始位点之间体外转录元件的演示
2. Sox10 acts as a tissue-specific transcription factor enhancing activation of the myelin basic protein gene promoter by p27Kip1 and Sp1. [J] . Wei Q, Miskimins WK, Miskimins R Journal of Neuroscience Research . 2004,第6期

机译：Sox10作为组织特异性转录因子，可增强p27Kip1和Sp1对髓鞘碱性蛋白基因启动子的激活。
3. A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells. [J] . S Haas, P Thatikunta, A Steplewski, Journal of cell biology . 1995,第5期

机译：来自小鼠脑的39 kD DNA结合蛋白刺激少突胶质细胞中髓鞘碱性蛋白基因的转录。
4. T cell receptor altered peptide ligands of Myelin Basic Protein and Proteolipid Protein (Linear and Cyclic) can modulate immune responses in SJL/J mice: Bioactive peptides for Multiple Sclerosis [C] . Maria Katsara, Theodore Tselios, Spyros Deraos International Peptide Symposium . 2009

机译：T细胞受体改变髓鞘碱性蛋白质和蛋白质（线性和环状）的肽配体可以调节SJL / J小鼠中的免疫应答：用于多发性硬化的生物活性肽
5. The involvement of SP1 in myelin basic protein gene transcription. [D] . Guo, Lili. 2010

机译：SP1参与髓鞘碱性蛋白基因转录。
6. Tissue-specific in vitro transcription from the mouse myelin basic protein promoter. [O] . T Tamura, A Aoyama, T Inoue, 1989

机译：从小鼠髓鞘碱性蛋白启动子进行的组织特异性体外转录。
7. Tissue-specific in vitro transcription from the mouse myelin basic protein promoter. [O] . Tamura, T, Aoyama, A, Inoue, T, 1989

机译：从小鼠髓鞘碱性蛋白启动子进行的组织特异性体外转录。
8. Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema [R] . Veronesi, B., Jones, K., Gupta, S., 1991

机译：髓磷脂碱性蛋白 - 信使RNa（mBp-mRNa）在三乙基锡诱导的髓鞘水肿期间的表达

Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

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