A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

M Szyf; G Tanigawa; P L McCarthy

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A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

机译：来自Thy-1基因的DNA信号定义了胚胎干细胞中的从头甲基化模式。

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Although DNA can be extensively methylated de novo when introduced into pluripotent cells, the CpG island in the Thy-1 gene does not become methylated either in the mouse embryo or in embryonic stem cells. A 214-base-pair region near the promoter of the Thy-1 gene protects itself as well as heterologous DNA sequences from de novo methylation. We propose that this nucleotide sequence is representative of a class of important signals that limits de novo methylation in the embryo and establishes the pattern of hypomethylated CpG dinucleotides found in somatic tissues.

机译：尽管将DNA引入多能细胞后可以被彻底地甲基化，但是Thy-1基因中的CpG岛在小鼠胚胎或胚胎干细胞中都不会甲基化。 Thy-1基因启动子附近的214个碱基对区域可保护自己以及异源DNA序列免受从头甲基化的影响。我们提出，该核苷酸序列代表一类重要信号，该信号限制了胚胎中的从头甲基化，并建立了在体细胞组织中发现的低甲基化CpG二核苷酸的模式。

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《Molecular and Cellular Biology》 |1990年第8期|共5页
作者
M Szyf; G Tanigawa; P L McCarthy;
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中图分类细胞生物学;
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1. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. [J] . Okano M, Xie S, Li E Nucleic Acids Research . 1998,第11期

机译：从头开始并在胚胎干细胞中维持病毒DNA的甲基化不需要Dnmt2。
2. An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation [J] . Petell Christopher J., Alabdi Lama, He Ming, Nucleic Acids Research . 2016,第16期

机译：表观遗传开关调节胚胎干细胞分化过程中多能性基因增强子的从头DNA甲基化
3. An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation [J] . Ming He, Humaira Gowher, Phillip San?Miguel, Nucleic acids research . 2016,第16期

机译：表观遗传开关调节胚胎干细胞分化过程中多能性基因增强子的从头DNA甲基化
4. Prediction of DNA methylation for every CpG loci in chromosome 18 in embryonic stem cells using support vector machine [C] . Asmaa Abo BakrKamel, Mai S. Mabrouk, Mohamed Waleed Fakhr International Computer Engineering Conference . 2017

机译：使用支持向量机预测胚胎干细胞中18号染色体上每个CpG位点的DNA甲基化
5. Characterization of DNA methylation patterns in tumorigenesis and the use of DNA methylation analysis to gauge toxic potential. [D] . Watson, Rebecca Erin. 2004

机译：DNA甲基化模式在肿瘤发生中的表征，以及使用DNA甲基化分析来测定毒性潜力。
6. A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [O] . M Szyf, G Tanigawa, P L McCarthy Jr 1990

机译：来自Thy-1基因的DNA信号定义了胚胎干细胞中的从头甲基化模式。
7. A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [O] . Szyf, M, Tanigawa, G, McCarthy, P L 1990

机译：来自Thy-1基因的DNA信号定义了胚胎干细胞中的从头甲基化模式。

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

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