Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

S Schwartz; B K Felber; G N Pavlakis

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Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

机译：单顺反子和多顺反子人类免疫缺陷病毒1型mRNA的翻译机制。

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We have used a panel of cDNA clones expressing wild-type and mutant human immunodeficiency virus type 1 (HIV-1) mRNAs to study translation of these mRNAs in eucaryotic cells. The tat open reading frame (ORF) has a strong signal for translation initiation, while rev and vpu ORFs have weaker signals. The expression of downstream ORFs is inhibited in mRNAs that contain the tat ORF as the first ORF. In contrast, downstream ORFs are expressed efficiently from mRNAs that have rev or vpu as the first ORF. All env mRNAs contain the upstream vpu ORF. Expression of HIV-1 Env protein requires a weak vpu AUG, which allows leaky scanning to occur, thereby allowing ribosomes access to the downstream env ORF. We concluded that HIV-1 mRNAs are translated by the scanning mechanism and that expression of more than one protein from each mRNA was caused by leaky scanning at the first AUG of the mRNA.

机译：我们已经使用一组表达野生型和突变型人类免疫缺陷病毒1型（HIV-1）mRNA的cDNA克隆来研究这些mRNA在真核细胞中的翻译。 tat开放阅读框（ORF）的翻译启动信号较强，而rev和vpu ORF的信号较弱。在包含tat ORF作为第一个ORF的mRNA中，下游ORF的表达受到抑制。相反，从具有rev或vpu作为第一个ORF的mRNA有效表达下游ORF。所有env mRNA均包含上游vpu ORF。 HIV-1 Env蛋白的表达需要弱的vpu AUG，这会导致扫描泄漏，从而使核糖体进入下游env ORF。我们得出的结论是，HIV-1 mRNA通过扫描机制进行翻译，并且每种mRNA中一种以上蛋白的表达是由mRNA的第一个AUG处的漏扫描引起的。

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《Molecular and Cellular Biology》 |1992年第1期|共13页
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S Schwartz; B K Felber; G N Pavlakis;
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中图分类细胞生物学;
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1. The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. [J] . D M DAgostino, B K Felber, J E Harrison, Molecular and Cellular Biology . 1992,第3期

机译：1型人类免疫缺陷病毒的Rev蛋白促进多体体结合和gag / pol和vpu / env mRNA的翻译。
2. Selective Pressure Against AUG Triplets in the 5′ Untranslated Region of Human Immunodeficiency Virus Type 1 Supports Cap-Dependent Translation Initiation Mechanism [J] . Sam Khalouei, Xuhua Xia Retrovirology: Research and Treatment . 2008,第2期

机译：针对人类免疫缺陷病毒1型5'非翻译区中AUG三联体的选择性压力支持依赖于帽的翻译起始机制
3. Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5' untranslated regions are efficiently translated in cells by a cap-dependent mechanism. [J] . Belsham GJ, Nielsen I, Normann P, RNA . 2008,第8期

机译：含有缺陷的丙型肝炎病毒样小核糖核酸病毒内部核糖体进入位点元件的5'非翻译区的单顺反子mRNA通过帽依赖性机制在细胞中有效翻译。
4. Brain-Derived Neurotrophic Factor Prevents Human Immunodeficiency Prevents Human Immunodeficiency Virus Type 1 Protein gp120 Neurotoxicityin the Rat Nigrostriatal System [C] . ITALO MOCCHETTI, RACHEL L. NOSHENY, GIANLUIGI TANDA, International Conference on Neuroprotective Agents: Clinical and Experimental Aspects . 2007

机译：脑衍生的神经营养因子可防止人类免疫缺陷可防止人类免疫缺陷病毒1型蛋白GP120神经毒性素大鼠核心瘤系统
5. Human immunodeficiency virus type 1 envelope glycoprotein-dependent and -independent mechanisms of dendritic cell-mediated virus capture and trans infection. [D] . Hatch, Steven Carter. 2010

机译：人类免疫缺陷病毒1型包膜树突状细胞介导的病毒捕获和反式感染的包膜糖依赖性和非依赖性机制。
6. Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs. [O] . S Schwartz, B K Felber, G N Pavlakis 1992

机译：单顺反子和多顺反子人类免疫缺陷病毒1型mRNA的翻译机制。
7. Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs. [O] . Schwartz, S, Felber, B K, Pavlakis, G N 1992

机译：单顺反子和多顺反子人类免疫缺陷病毒1型mRNA的翻译机制。
8. Report on Carcinogens (RoC) Concept: Selected Viruses. Epstein--Barr Virus, Human ImmunodeficiencynVirus Type 1, Human T--Cell Lymphotropic Virus Type 1, Kaposi Sarcoma--Associated Herpes Virus, and nMerkel Cell Polyoma Virus. [R] . 2016

机译：关于致癌物（RoC）概念的报告：选定的病毒。爱泼斯坦 - 巴尔病毒，人类免疫缺陷病毒1型，人类T细胞淋巴细胞病毒1型，卡波西肉瘤 - 相关疱疹病毒和nmerkel细胞多瘤病毒。

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

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