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Functional organization of the hepatitis B virus enhancer.

机译：乙肝病毒增强剂的功能组织。

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We have studied the functional constituents of the hepatitis B virus enhancer in a number of cell lines. The sequence of this enhancer, being embedded within an open reading frame of the virus, is in part evolutionarily frozen and therefore serves as a good model to investigate the fundamental enhancer elements. The hepatitis B virus enhancer contains three functionally important DNA sequence elements, EP, E, and NF-1a, each of which is bound by a distinct protein(s). The synergistic action of these elements accounts for all of the enhancer activity in a nonliver cell line and for most, but not all, of the activity in liver-derived cell lines. Multimers of the E but not of the EP element act as an autonomous enhancer. Conversely, a single element of either the E or the NF-1a element can act only when linked to the EP element. These results suggest that EP is a crucial enhancer element that acts only in interaction with a second enhancer element with intrinsic enhancer activity. Interestingly, a highly similar enhancer structure is found in a number of distinct viruses.
机译：我们已经研究了许多细胞系中乙型肝炎病毒增强剂的功能成分。嵌入病毒开放阅读框内的这种增强子的序列在部分进化过程中被冻结，因此可作为研究基本增强子元件的良好模型。乙型肝炎病毒增强剂包含三个功能上重要的DNA序列元素：EP，E和NF-1a，每个元素均由不同的蛋白质结合。这些元素的协同​​作用解释了非肝细胞系中所有增强子的活性，以及​​肝来源细胞系中大多数但不是全部的活性。 E而不是EP元件的多聚体充当自主增强剂。相反，E或NF-1a元素中的单个元素只有在链接到EP元素时才能起作用。这些结果表明，EP是关键的增强子元件，其仅与具有固有增强子活性的第二增强子元件相互作用而起作用。有趣的是，在许多不同的病毒中发现了高度相似的增强子结构。

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